Daf-7
| abnormal dauer formation protein 7 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-7 | ||||||
| Entrez | 175237 | ||||||
| HomoloGene | 21183 | ||||||
| RefSeq (mRNA) | NM_064864.5 | ||||||
| RefSeq (Prot) | NP_497265.1 | ||||||
| UniProt | P92172 | ||||||
| Other data | |||||||
| Chromosome | III: 0.81 - 0.81 Mb | ||||||
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The DAF-7 gene encodes for the ortholog of GDF11, a ligand of TGF-beta signaling pathway, in the worm Caenorhabditis elegans.[1] When binds to the complex of type II receptor Daf-4 and type I receptor Daf-1, this receptor protein serine/threonine kinase will phosphorylation activate the Smad Protein Daf-8/14.[2]
References
[edit]- ^ Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6284–8. Bibcode:2001PNAS...98.6284M. doi:10.1073/pnas.111409798. PMC 33460. PMID 11353865.
- ^ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.
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