DLEU1

DLEU1
Identifiers
Aliases	DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6, deleted in lymphocytic leukemia 1 (non-protein coding), deleted in lymphocytic leukemia 1
External IDs	OMIM: 605765; GeneCards: DLEU1; OMA:DLEU1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	50,906,856 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; islet of Langerhans; ; sural nerve; ; epithelium of colon; ; ventricular zone; ; Achilles tendon; ; monocyte; ; bone marrow cells; ; muscle of thigh;
	n/a
	More reference expression data
	n/a
Orthologs
	10301
	n/a
	ENSG00000176124
	n/a
	n; a
	n/a
	NM_005887
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

In molecular biology, deleted in lymphocytic leukemia 1 (non-protein coding), also known as DLEU1, is a long non-coding RNA. In humans it is located on chromosome 13q14. The DLEU1 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.^[3] It was later discovered to be a long non-coding RNA with over 20 different splice variants.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176124 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grandér D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultström AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D (Nov 1997). "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene. 15 (20): 2463–2473. doi:10.1038/sj.onc.1201643. PMID 9395242. S2CID 21133945.
^ Wolf S, Mertens D, Schaffner C, Korz C, Döhner H, Stilgenbauer S, Lichter P (Jun 2001). "B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions". Human Molecular Genetics. 10 (12): 1275–1285. doi:10.1093/hmg/10.12.1275. PMID 11406609.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Kapanadze B, Makeeva N, Corcoran M, Jareborg N, Hammarsund M, Baranova A, Zabarovsky E, Vorontsova O, Merup M, Gahrton G, Jansson M, Yankovsky N, Einhorn S, Oscier D, Grandér D, Sangfelt O (Dec 2000). "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14". Genomics. 70 (3): 327–334. doi:10.1006/geno.2000.6386. PMID 11161783.
Mertens D, Philippen A, Ruppel M, Allegra D, Bhattacharya N, Tschuch C, Wolf S, Idler I, Zenz T, Stilgenbauer S (Mar 2009). "Chronic lymphocytic leukemia and 13q14: miRs and more". Leukemia & Lymphoma. 50 (3): 502–505. doi:10.1080/10428190902763509. PMID 19347735. S2CID 9204581.
Polasek O, Marusić A, Rotim K, Hayward C, Vitart V, Huffman J, Campbell S, Janković S, Boban M, Biloglav Z, Kolcić I, Krzelj V, Terzić J, Matec L, Tometić G, Nonković D, Nincević J, Pehlić M, Zedelj J, Velagić V, Juricić D, Kirac I, Belak Kovacević S, Wright AF, Campbell H, Rudan I (Feb 2009). "Genome-wide association study of anthropometric traits in Korcula Island, Croatia". Croatian Medical Journal. 50 (1): 7–16. doi:10.3325/cmj.2009.50.7. PMC 2657571. PMID 19260139.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176124 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9395242-3] Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grandér D, Iyengar A, Baranova A, Kashuba V, Merup M, Wu X, Gardiner A, Mullenbach R, Poltaraus A, Hultström AL, Juliusson G, Chapman R, Tiller M, Cotter F, Gahrton G, Yankovsky N, Zabarovsky E, Einhorn S, Oscier D (Nov 1997). "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia". Oncogene. 15 (20): 2463–2473. doi:10.1038/sj.onc.1201643. PMID 9395242. S2CID 21133945.

[pmid11406609-4] Wolf S, Mertens D, Schaffner C, Korz C, Döhner H, Stilgenbauer S, Lichter P (Jun 2001). "B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions". Human Molecular Genetics. 10 (12): 1275–1285. doi:10.1093/hmg/10.12.1275. PMID 11406609.

[1]

[2]

[3]

[4]

DLEU1

See also

References

Further reading