DCHS2

DCHS2
Identifiers
Aliases	DCHS2, CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDs	OMIM: 612486; HomoloGene: 130686; GeneCards: DCHS2; OMA:DCHS2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	154,491,799 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Achilles tendon; ; superior frontal gyrus; ; nucleus accumbens; ; smooth muscle tissue; ; muscle layer of sigmoid colon; ; sural nerve; ; body of uterus; ; myometrium; ; caudate nucleus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; molecular function; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; membrane; cellular component;
Biological process	cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; biological process; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54798
	n/a
	ENSG00000197410; ENSG00000284227
	n/a
	Q6V1P9
	n/a
	NM_001142552; NM_001142553; NM_017639; NM_199348; NM_001358235
	n/a
	NP_001136024; NP_001345164
	n/a
	Wikidata
View/Edit Human

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.^[3]^[4]

DCHS2 has been implicated in the nose angle (how much a nose is upturned).^[5] As well as facial genetics ^[6]^[7]

References

^ ^a ^b ^c ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: dachsous 2 (Drosophila)".
^ Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, et al. (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". Journal of Molecular Biology. 337 (2): 307–317. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
^ Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC 4874031. PMID 27193062.
^ Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A (2018). "Facial Genetics: A Brief Overview". Frontiers in Genetics. 9: 462. doi:10.3389/fgene.2018.00462. PMC 6198798. PMID 30386375.
^ Firger J (19 May 2016). "Your nose--Big or small--is shaped by your DNA". Newsweek.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: dachsous 2 (Drosophila)".

[pmid15003449-4] Hoeng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, et al. (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". Journal of Molecular Biology. 337 (2): 307–317. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.

[nose-angle-5] Adhikari K, Fuentes-Guajardo M, Quinto-Sánchez M, Mendoza-Revilla J, Camilo Chacón-Duque J, Acuña-Alonzo V, et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616. Bibcode:2016NatCo...711616A. doi:10.1038/ncomms11616. PMC 4874031. PMID 27193062.

[facial-genetics-6] Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A (2018). "Facial Genetics: A Brief Overview". Frontiers in Genetics. 9: 462. doi:10.3389/fgene.2018.00462. PMC 6198798. PMID 30386375.

[nose-big-small-7] Firger J (19 May 2016). "Your nose--Big or small--is shaped by your DNA". Newsweek.

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References

Further reading