D75-4590

D75-4590
Names
	IUPAC name 1-{[2-(Diethylamino)ethyl]amino}-2-ethyl-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
	Other names 4-[2-(Diethylamino)ethylamino]-3-ethyl-2-methyl-4a,9-diaza-3,4-dihydrofluorene-1-carbonitrile
Identifiers
CAS Number	384376-42-5 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1171572;
ChemSpider	824252;
PubChem CID	948175;
UNII	PS449L7PJY ;
CompTox Dashboard (EPA)	DTXSID201045514 ;
	InChI InChI=1S/C21H27N5/c1-5-16-15(4)17(14-22)21-24-18-10-8-9-11-19(18)26(21)20(16)23-12-13-25(6-2)7-3/h8-11,23H,5-7,12-13H2,1-4H3 Key: DMKNXKIUSPUYQP-UHFFFAOYSA-N;
	SMILES CCc1c(c(c2nc3ccccc3n2c1NCCN(CC)CC)C#N)C;
Properties
Chemical formula	C21H27N5
Molar mass	349.473 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

D75-4590 is an antifungal pyridobenzimidazole derivative that inhibits β-glucan synthesis. D11-2040 and D21-6076 are antifungal derivatives of D75-4590.^[1]^[2]

References

^ Kitamura, Akihiro; Someya, Kazuhiko; Hata, Masato; Nakajima, Ryohei; Takemura, Makoto (2008). "Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis". Antimicrobial Agents and Chemotherapy. 53 (2): 670–7. doi:10.1128/AAC.00844-08. PMC 2630612. PMID 19015325.
^ Kitamura, Akihiro; Someya, Kazuhiko; Okumura, Ryo; Hata, Masato; Takeshita, Hiroshi; Nakajima, Ryohei (2010). "In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs". Biological & Pharmaceutical Bulletin. 33 (2): 192–7. doi:10.1248/bpb.33.192. PMID 20118539.

[1] Kitamura, Akihiro; Someya, Kazuhiko; Hata, Masato; Nakajima, Ryohei; Takemura, Makoto (2008). "Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis". Antimicrobial Agents and Chemotherapy. 53 (2): 670–7. doi:10.1128/AAC.00844-08. PMC 2630612. PMID 19015325.

[2] Kitamura, Akihiro; Someya, Kazuhiko; Okumura, Ryo; Hata, Masato; Takeshita, Hiroshi; Nakajima, Ryohei (2010). "In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs". Biological & Pharmaceutical Bulletin. 33 (2): 192–7. doi:10.1248/bpb.33.192. PMID 20118539.

[1]

[2]