D-alanine—alanyl-poly(glycerolphosphate) ligase
| D-Alanine—alanyl-poly(glycerolphosphate) ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.2.16 | ||||||||
| CAS no. | 9046-58-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a D-alanine—alanyl-poly(glycerolphosphate) ligase (EC 6.3.2.16) is an enzyme that catalyzes the chemical reaction
- ATP + D-alanine + alanyl-poly(glycerolphosphate) ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate)
The 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly(glycerolphosphate), whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly(glycerolphosphate).
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming). Other names in common use include D-alanyl-alanyl-poly(glycerolphosphate) synthetase, D-alanine:membrane-acceptor ligase, D-alanylalanylpoly(phosphoglycerol) synthetase, D-alanyl-poly(phosphoglycerol) synthetase, and D-alanine-membrane acceptor-ligase. This enzyme participates in d-alanine metabolism.
References
[edit]- Reusch VM, Neuhaus FC (October 1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". The Journal of Biological Chemistry. 246 (20): 6136–43. PMID 4399593.
