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Cuilin Zhang

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Cuilin Zhang
Alma materBeijing Medical University
University of Washington School of Public Health
Scientific career
FieldsEpidemiology
InstitutionsHarvard T.H. Chan School of Public Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development
ThesisVariants in the Lipoprotein Lipase Gene and Paraoxonase Gene and Risk of Preeclampsia (2003)
Doctoral advisorMichelle Ann Williams

Cuilin Zhang is a Chinese-American epidemiologist and physician-scientist researching the roles of genetic and environmental factors in the pathogenesis of gestational diabetes, type 2 diabetes, and obesity and health consequences of these complications. Zhang is a senior investigator and acting chief of the epidemiology branch at the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Education

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Zhang completed a M.D. at Beijing Medical University in 1993. She earned a M.P.H. (1999) and Ph.D. in epidemiology (2004) at the University of Washington School of Public Health.[1][2] Zhang's dissertation was titled Variants in the Lipoprotein Lipase Gene and Paraoxonase Gene and Risk of Preeclampsia. Her doctoral advisor was Michelle Ann Williams.[3] Zhang received postdoctoral training in genetic and nutritional epidemiology at Harvard University.[2]

Career

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Zhang worked as a research scientist at the Harvard T.H. Chan School of Public Health.[2] In 2007, she joined the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in 2007. Zhang is a tenure-track senior investigator[2] and the acting chief of the epidemiology branch.[4]

Research

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Zhang's research interest is at the interface of genetic and non-genetic biological markers and potentially modifiable exogenous factors, focusing on their interplay in relation to the development of complex diseases. More specifically, her current research activities focus primarily on the roles of genetic and environmental factors in the pathogenesis of gestational diabetes, type 2 diabetes, and obesity and health consequences of these complications. Zhang also has long-standing research interests in fetal origins of chronic diseases, life course epidemiology, and modifications of diet and lifestyle to improve reproductive outcomes and child health.[4][5][6]

Zhang serves as the principal investigator of the diabetes and women's health study, which is a retrospective cohort study of approximately 4,000 women from U.S. and Denmark who had diabetes in pregnancy and have been followed up for at least 10 years. These women will be prospectively followed up for an additional four years to collect updated information on major environmental factors and timed biospecimens. The study is focusing on the identification of determinants (medical, lifestyle, genetic and their interactions) for the progression from gestational diabetes to type 2 diabetes and its complications and the investigation of biochemical markers that may predict the development of these complications among the pre-diabetic population.[4][7] The results of one of Zhang's studies suggests that physical activity and a healthy diet may prevent the occurrence of type 2 diabetes in women who are at a heightened risk.[8] A study Zhang led found that women who have had gestational diabetes may be able to reduce or even eliminate their elevated risk for cardiovascular disease by following a healthy lifestyle in the years after giving birth. Zhang and her team analyzed data from the Nurses' Health Study, which followed health habits and medical history of more than 90,000 women from before pregnancy through middle age and the early senior years. The study confirms the links between gestational diabetes and cardiovascular disease found by other studies. It also provides some strong evidence that cardiovascular disease after gestational diabetes is not inevitable for women who adopt a healthy diet, maintain a healthy weight, exercise moderately, and do not smoke. In this study, the researchers found that women who failed to adopt a healthy lifestyle in the wake of gestational diabetes had a 43 percent higher risk for cardiovascular disease, particularly heart attack and stroke.[9][10]

Zhang is also the principal investigator of the investigation of the risk factors and pathogenesis of gestational diabetes using biospecimens longitudinally collected from prospective pregnancy cohorts. Currently, the study focuses on a comprehensive panel of biochemical markers and epigenetic markers that are putatively implicated in glucose homeostasis, fetal growth, or both. Non-targeted metabolomics will also be analyzed for the discovery of new pathways and/or biochemical markers related to glucose intolerance and subsequent adverse fetal outcomes.[4] In one of Zhang's studies, her findings suggested that a diet rich in potatoes could potentially increase the risk of gestational diabetes.[11][12]

Zhang has published a number of papers and book chapters focusing on the determinants of gestational diabetes, preeclampsia, type 2 diabetes and its complications, and obesity including genetic factors, diet and lifestyle factors, and biochemical markers.[4][13] In 2018, Zhang and her team's research explored factors increasing the chances of macrosomia.[14] In 2020, she contributed to research led by Xiang Gao and Muzi Na that investigated possible connections between restless legs syndrome during pregnancy and race and ethnicity.[15]

Personal life

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Zhang plays the guqin.[16]

Selected works

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References

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  1. ^ "Cuilin Zhang - Faculty Directory". Johns Hopkins Bloomberg School of Public Health. Archived from the original on 16 June 2017. Retrieved 18 March 2021.
  2. ^ a b c d "Principal Investigators". NIH Intramural Research Program. Archived from the original on 5 March 2022. Retrieved 18 March 2021.Public Domain This article incorporates text from this source, which is in the public domain.
  3. ^ Zhang, Cuilin (2003). Variants in the Lipoprotein Lipase Gene and Paraoxonase Gene and Risk of Preeclampsia (Ph.D. thesis). University of Washington. OCLC 55704508.
  4. ^ a b c d e "Epidemiology Branch (EB)". Eunice Kennedy Shriver National Institute of Child Health and Human Development. Archived from the original on 4 January 2018. Retrieved 18 March 2021.Public Domain This article incorporates text from this source, which is in the public domain.
  5. ^ "Fetuses grow differently in obese women". Reuters. Retrieved 18 March 2021.
  6. ^ "Healthful Diet Staves Off Hypertension in Women with a History of Gestational Diabetes". EndocrineWeb. Retrieved 18 March 2021.
  7. ^ Rapaport, Lisa (4 December 2015). "Low-carb diet doesn't always cut diabetes risk after pregnancy". Reuters. Retrieved 18 March 2021.
  8. ^ Kuehn, Bridget M. (11 June 2014). "Physical Activity May Stave Off Diabetes for Women at Risk". JAMA. 311 (22): 2263. doi:10.1001/jama.2014.6862. ISSN 0098-7484. PMID 24915243.
  9. ^ "Research Briefs". NIH Catalyst. 31 October 2017. Archived from the original on 20 March 2020. Retrieved 17 April 2021.Public Domain This article incorporates text from this source, which is in the public domain.
  10. ^ Tobias, Deirdre K.; Stuart, Jennifer J.; Li, Shanshan; Chavarro, Jorge; Rimm, Eric B.; Rich-Edwards, Janet; Hu, Frank B.; Manson, JoAnn E.; Zhang, Cuilin (1 December 2017). "Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women". JAMA Internal Medicine. 177 (12): 1735–1742. doi:10.1001/jamainternmed.2017.2790. ISSN 2168-6106. PMC 5820722. PMID 29049820.
  11. ^ Marcus, Mary Brophy (13 January 2016). "Should women avoid potatoes before pregnancy?". CBS. Archived from the original on 16 January 2016. Retrieved 18 March 2021.
  12. ^ "Potato-rich diet 'may increase pregnancy diabetes risk'". BBC News. 13 January 2016. Retrieved 18 March 2021.
  13. ^ Ford, Steve (22 May 2018). "Gestational diabetes may be risk factor for chronic kidney disease". Nursing Times. Retrieved 18 March 2021.
  14. ^ Hewings-Martin, Yella (16 November 2017). "5 surprising facts about obesity". Medical News Today. Fact checked by Jasmin Collier. Archived from the original on 21 January 2021. Retrieved 16 April 2021.
  15. ^ "Race and ethnicity may not play role in restless leg syndrome during pregnancy". Penn State News. 12 November 2020. Archived from the original on 15 November 2020. Retrieved 16 April 2021.
  16. ^ "Colleagues: Recently Tenured". NIH Intramural Research Program. 15 January 2015. Retrieved 17 April 2021.Public Domain This article incorporates text from this source, which is in the public domain.
Public Domain This article incorporates public domain material from websites or documents of the National Institutes of Health.
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