Cotadutide
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Other names | MEDI-0382 |
Routes of administration | Subcutaneous injection |
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Formula | C167H252N42O55 |
Molar mass | 3728.092 g·mol−1 |
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Cotadutide is an experimental drug for the treatment of type 2 diabetes mellitus. It lowers blood glucose levels by mimicking the human hormones glucagon-like peptide 1 and glucagon, which play a role in blood sugar regulation. The drug is a peptide that is injected under the skin.[1][2]
Cotadutide is in Phase II clinical trials as of February 2021[update].[3] Cotadutide, a therapeutic agent, was undergoing Phase II clinical trials. This stage of trials typically involves evaluating the drug's effectiveness and further assessing its safety in a larger group of participants, compared to earlier phases.[citation needed]
See also
[edit]References
[edit]- ^ Parker VE, Robertson D, Wang T, Hornigold DC, Petrone M, Cooper AT, et al. (March 2020). "Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist". The Journal of Clinical Endocrinology and Metabolism. 105 (3): 803–820. doi:10.1210/clinem/dgz047. PMID 31608926. S2CID 204546248.
- ^ Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, et al. (December 2016). "Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates". Diabetes, Obesity & Metabolism. 18 (12): 1176–1190. doi:10.1111/dom.12735. PMC 5129521. PMID 27377054.
- ^ "Cotadutide". ClinicalTrials.gov. Retrieved 2021-02-18.