Copper ibuprofenate
_Ibuprofenate.jpg)
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| Names | |
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| IUPAC name
bis[2-(4-isobutylphenyl)propionato]copper(II)
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| Identifiers | |
3D model (JSmol)
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| Properties | |
| C52H68Cu2O8 | |
| Molar mass | 948.200 g·mol−1 |
| Appearance | Green powder |
| Slightly soluble | |
| Solubility in isopropanol | Slightly soluble |
| Related compounds | |
Related compounds
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Copper aspirinate |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Copper ibuprofenate is a chemical complex consisting of copper(II) and the chelate form of the anti-inflammatory drug ibuprofen.[1][2] The compound is prepared by the reaction of sodium ibuprofenate with copper(II) sulfate.
It has been suggested that copper complexes of anti-inflammatory drugs are more active than the parent drug[3] and produce fewer gastrointestinal side-effects.[4] In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.[5]
References
[edit]- ^ Frazier, D. R.; S. K. Lynch; G. O. Carlisle (1981). "Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II)". Journal of Inorganic and Nuclear Chemistry. 43 (11): 2747–2748. doi:10.1016/0022-1902(81)80610-0.
- ^ Abuhijleh AL (September 1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem. 55 (4): 255–62. doi:10.1016/0162-0134(94)85010-0. PMID 7964714.
- ^ Sorenson JR (1989). "Copper complexes offer a physiological approach to treatment of chronic diseases". Prog Med Chem. Progress in Medicinal Chemistry. 26: 437–568. doi:10.1016/s0079-6468(08)70246-7. ISBN 9780444810380. PMID 2690187.
- ^ Gordijo CR, Barbosa CA, Da Costa Ferreira AM, Constantino VR, de Oliveira Silva D (May 2005). "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci. 94 (5): 1135–48. doi:10.1002/jps.20336. PMID 15793807.
- ^ US patent 7462227, Anderson, Albert Gordon; Feaster, John; Patel, Damini; Scialdone, Mark, "Ibuprofen complexes as wood preservatives", issued 2007-07-26
Further reading
[edit]- A. Latif, Abuhijleh (1997). "Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage". Polyhedron. 16 (4): 733–740. doi:10.1016/0277-5387(96)00214-8.