Comutagen

A comutagen is a substance that is not a mutagen by itself, but in the presence of a mutagen, enhances mutagenic activity.^[1] There are at least two manners by which this may occur; the comutagen may strengthen the mutagenic activity of mutagenic chemicals, or it can create a mutagenic response from nonmutagens.^[2] Chemicals such as harmane and norharmane (present in tobacco tar) have been identified as comutagens.^[3]

References

^ National Research Council (US) Committee on Diet, Nutrition, and Cancer (1982). Diet, Nutrition, and Cancer. National Academic Press.{{cite book}}: CS1 maint: multiple names: authors list (link)
^ Shamberger, R. (2012). Nutrition and Cancer. Springer US. p. 274. ISBN 978-1-4684-4670-8. Retrieved 28 August 2018. Modifiers of mutagenicity can be either comutagens or antimutagens. Comutagens are substances that enhance the mutagenic activity of a chemical even though it is not in itself mutagenic.
^ De Serr, F.J.; Hollaender, A. (2013). Chemical Mutagens: Principles and Methods for Their Detection. Springer US. p. 52. ISBN 978-1-4613-3072-1. Retrieved 28 August 2018. Norharman and harman interfere with the metabolism of many mutagens/carcinogens, enhancing or depressing their mutagenicities. When norharman increases mutagenicity, its action can be called "comutagenic."

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[1] National Research Council (US) Committee on Diet, Nutrition, and Cancer (1982). Diet, Nutrition, and Cancer. National Academic Press.{{cite book}}: CS1 maint: multiple names: authors list (link)

[Shamberger_2012_p._274-2] Shamberger, R. (2012). Nutrition and Cancer. Springer US. p. 274. ISBN 978-1-4684-4670-8. Retrieved 28 August 2018. Modifiers of mutagenicity can be either comutagens or antimutagens. Comutagens are substances that enhance the mutagenic activity of a chemical even though it is not in itself mutagenic.

[De_Serr_Hollaender_2013_p._52-3] De Serr, F.J.; Hollaender, A. (2013). Chemical Mutagens: Principles and Methods for Their Detection. Springer US. p. 52. ISBN 978-1-4613-3072-1. Retrieved 28 August 2018. Norharman and harman interfere with the metabolism of many mutagens/carcinogens, enhancing or depressing their mutagenicities. When norharman increases mutagenicity, its action can be called "comutagenic."

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