Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1gene.[5][6]
This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix.
Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gerecke DR, Olson PF, Koch M, Knoll JH, Taylor R, Hudson DL, et al. (April 1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics. 41 (2): 236–242. doi:10.1006/geno.1997.4638. PMID9143499.
Oh SP, Taylor RW, Gerecke DR, Rochelle JM, Seldin MF, Olsen BR (October 1992). "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6". Genomics. 14 (2): 225–231. doi:10.1016/S0888-7543(05)80210-1. PMID1427837.
Wälchli C, Koch M, Chiquet M, Odermatt BF, Trueb B (February 1994). "Tissue-specific expression of the fibril-associated collagens XII and XIV". Journal of Cell Science. 107 ( Pt 2) (2): 669–681. doi:10.1242/jcs.107.2.669. PMID8207089.
Wessel H, Anderson S, Fite D, Halvas E, Hempel J, SundarRaj N (October 1997). "Type XII collagen contributes to diversities in human corneal and limbal extracellular matrices". Investigative Ophthalmology & Visual Science. 38 (11): 2408–2422. PMID9344363.
Trächslin J, Koch M, Chiquet M (March 1999). "Rapid and reversible regulation of collagen XII expression by changes in tensile stress". Experimental Cell Research. 247 (2): 320–328. doi:10.1006/excr.1998.4363. PMID10066359.
Saika S, Miyamoto T, Tanaka T, Ishida I, Ohnishi Y, Ooshima A (December 2001). "Collagens XII and XIV (FACITs) in capsular opacification and in cultured lens epithelial cells". Current Eye Research. 23 (6): 463–468. doi:10.1076/ceyr.23.6.463.6971. PMID12045897. S2CID41275312.
Jin X, Iwasa S, Okada K, Ooi A, Mitsui K, Mitsumata M (August 2003). "Shear stress-induced collagen XII expression is associated with atherogenesis". Biochemical and Biophysical Research Communications. 308 (1): 152–158. doi:10.1016/S0006-291X(03)01344-5. PMID12890494.
Thierry L, Geiser AS, Hansen A, Tesche F, Herken R, Miosge N (November 2004). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". Journal of Molecular Histology. 35 (8–9): 803–810. doi:10.1007/s10735-004-1132-y. PMID15609093. S2CID30409158.