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Cohesin domain

From Wikipedia, the free encyclopedia
Cohesin
single cohesin domain from the scaffolding protein cipa of the clostridium thermocellum cellulosome
Identifiers
SymbolCohesin
PfamPF00963
Pfam clanCL0203
InterProIPR002102
SCOP21anu / SCOPe / SUPFAM
CDDcd08546
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.[1]

The scaffolding component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.

References

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  1. ^ Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, Frolow F (March 1997). "A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly". Structure. 5 (3): 381–90. doi:10.1016/s0969-2126(97)00195-0. PMID 9083107.
This article incorporates text from the public domain Pfam and InterPro: IPR002102
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