Cohesin domain
Appearance
Cohesin | |||||||||
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Identifiers | |||||||||
Symbol | Cohesin | ||||||||
Pfam | PF00963 | ||||||||
Pfam clan | CL0203 | ||||||||
InterPro | IPR002102 | ||||||||
SCOP2 | 1anu / SCOPe / SUPFAM | ||||||||
CDD | cd08546 | ||||||||
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In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.[1]
The scaffolding component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.
References
[edit]- ^ Shimon LJ, Bayer EA, Morag E, Lamed R, Yaron S, Shoham Y, Frolow F (March 1997). "A cohesin domain from Clostridium thermocellum: the crystal structure provides new insights into cellulosome assembly". Structure. 5 (3): 381–90. doi:10.1016/s0969-2126(97)00195-0. PMID 9083107.
External links
[edit]- Media related to Cohesin domain at Wikimedia Commons