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Chuan-Pu Lee

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Chuan-pu Lee
Born1931
Qingdao, Shandong, China
DiedJuly 20, 2016
Detroit, Michigan, US
Occupation(s)Biochemist, college professor

Chuan-pu Lee (1931 – 2016) was an American biochemist, born in China. She was a professor of biochemistry at the Wayne State University School of Medicine from 1975 until her retirement in 2011. She was inducted into the Michigan Women's Hall of Fame in 2000.

Early life and education

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Lee was born in Qingdao, Shandong province, China, one of six children born to Fung-Hwa Lee and Wei-Ping Liu Lee.[1] She earned a bachelor's degree in chemistry at National Taiwan University in 1954, and completed doctoral studies at Oregon State University in 1961, under advisor Tsoo E. King. Her dissertation was titled "Biochemical Studies of Western Ring Spot Virus".[2] Her younger brother Chuan-kuo Lee also attended a University of Pennsylvania graduate program, in physics.[3]

Career

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Lee held a postdoctoral position at the University of Pennsylvania, working with Britton Chance, and became a professor of physical biochemistry there. She was a professor of biochemistry at the Wayne State University College of Medicine beginning in 1975,[4] with an additional appointment in the neurology department beginning in 1982. She also had a longtime association with Stockholm University, through her frequent collaborator Lars Ernster. Her research involved mitochondrial bioenergetics, or a study of how energy is produced in bodies at the cellular level. Her research was published in academic journals including Annual Review of Biochemistry,[5] European Journal of Biochemistry,[6] FEBS Letters,[7] Journal of Neurochemistry,[8] Methods in Enzymology,[9] and Biochemistry.[10] She retired in 2011.[11]

In 2000 Lee was named to the Michigan Women's Hall of Fame.[12][13] She established the Chuan-Pu Lee, Ph.D. Endowed Graduate Student Research Fund at Wayne State, granting funds for graduate student travel to academic conferences.[14]

Selected publications

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Lee was prolific in scientific publications, with over 200 journal articles written or co-written by her. Below, a selection from the years between 1964 and 2005 gives a sense of her subjects and collaborators. She also co-edited Mitochondria and microsomes (1981),[15] a collection of essays in honor of Lars Ernstner; and co-edited Membrane Bioenergetics (1979)[16] and edited Current Topics in Bioenergetics 13 (1984),[17] 14 (1985),[18] 15 (1987)[19] and 16 (1991).[20]

  • "Biological Oxidoreductions" (1964, with Lars Ernster)[5]
  • "Properties of mitochondria isolated from herring gull salt gland" (1964, with Britton Chance, Reiko Oshino, and George D. V. Van Rossum)[21]
  • "Stereochemistry of hydrogen-transfer in the energy-linked pyridine nucleotide transhydrogenase and related reactions" (1965, with L. Ernster, N. Simard-Duquesne, and H. D. Hoberman)[22]
  • "Energy-coupling in nonphosphorylating submitochondrial particles" (1967, with L. Ernster)[9]
  • "Studies of the Energy-Transfer System of Submitochondrial Particles" (1968, with L. Ernster)[6]
  • "Comparison of fluorescence probe and light-scattering readout of structural states of mitochondrial membrane fragments" (1969, with Britton Chance)[7]
  • Ion transport and energy conservation in submitochondrial particles" (1970, with Britton Chance and Maurice Montal)[23]
  • "Oxidation-reduction potentials of cytochromes in mitochondria" (1970, with P. Leslie Dutton and David Franklin Wilson)[10]
  • "Progressive Ophthalmoplegia, Glycogen Storage, and Abnormal Mitochondria" (1973, with Salvatore DiMauro, Donald L. Schotland, Eduardo Bonilla, Pierluigi Gambetti, and Lewis P. Rowland)[24]
  • "Neuromuscular Disorder Associated With a Defect in Mitochondrial Energy Supply" (1976, with Donald L. Schotland, Salvatore DiMauro, Eduardo Bonilla, and Antonio Scarpa)[25]
  • "Tightly coupled beef heart submitochondrial particles" (1979)[26]
  • "Reye's syndrome: salicylates and mitochondrial functions" (1984, with Margaret E. Martens)[27]
  • "Mitochondrial Encephalomyopathies" (1988, with Margaret E. Martens and Patti L. Peterson)[28]
  • "The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain" (2004, with Ye Xiong, Feng-Shiun Shie, Jing Zhang, and Ye-Shih Ho)[29]
  • "Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase" (2005, with Ye Xiong, Feng-Shiun Shie, Jing Zhang, and Ye-Shih Ho)[8]

Personal life

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Lee died in 2016, aged 84 years, at a hospital in Detroit.[11][14] Wayne State University holds an annual Chuan-Pu Lee, Ph.D. Endowed Graduate Student Research Presentation Day, in her memory.[30]

References

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  1. ^ "Chuan-Shue (Mike) Lee". The News Journal. 2019-08-09. pp. A12. Retrieved 2021-11-12.
  2. ^ "Chemistry Tree - Chuan-Pu Lee". AcademicTree. Archived from the original on 2021-11-12. Retrieved 2021-11-12.
  3. ^ "Chang-kuo Lee, PHD". The News Journal. 2015-03-01. pp. A33. Retrieved 2021-11-13 – via Newspapers.com.
  4. ^ Rzepka, Marianne (1980-03-19). "China Visit is Going Home for 2 WSU Profs". Detroit Free Press. p. 2. Retrieved 2021-11-13 – via Newspapers.com.
  5. ^ a b Ernster, L; Lee, C P (1964-06-01). "Biological Oxidoreductions". Annual Review of Biochemistry. 33 (1): 729–788. doi:10.1146/annurev.bi.33.070164.003501. ISSN 0066-4154. PMID 14268850.
  6. ^ a b Lee, Chuan-pu; Ernster, L. (1968). "Studies of the Energy-Transfer System of Submitochondrial Particles". European Journal of Biochemistry. 3 (4): 391–400. doi:10.1111/j.1432-1033.1967.tb19542.x. ISSN 1432-1033. PMID 4296030.
  7. ^ a b Chance, Britton; Lee, Chuan-pu (1969). "Comparison of fluorescence probe and light-scattering readout of structural states of mitochondrial membrane fragments". FEBS Letters. 4 (3): 181–184. doi:10.1016/0014-5793(69)80229-2. ISSN 1873-3468. PMID 11947177. S2CID 7689682.
  8. ^ a b Xiong, Ye; Shie, Feng-Shiun; Zhang, Jing; Lee, Chuan-Pu; Ho, Ye-Shih (2005). "Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase". Journal of Neurochemistry. 95 (3): 732–744. doi:10.1111/j.1471-4159.2005.03412.x. ISSN 1471-4159. PMID 16248885. S2CID 30705043.
  9. ^ a b Lee, Chuan-pu; Ernster, Lars (1967). "[87] Energy-coupling in nonphosphorylating submitochondrial particles". Oxidation and Phosphorylation. Methods in Enzymology. Vol. 10. Academic Press. pp. 543–548. doi:10.1016/0076-6879(67)10093-1. ISBN 9780121818500.
  10. ^ a b Dutton, P. Leslie; Wilson, David Franklin; Lee, Chuan-Pu (1970-12-01). "Oxidation-reduction potentials of cytochromes in mitochondria". Biochemistry. 9 (26): 5077–5082. doi:10.1021/bi00828a006. ISSN 0006-2960. PMID 4320585.
  11. ^ a b "Dr. Chuan-Pu Lee dies at age 84". School of Medicine News. 2019-03-08. Retrieved 2021-11-12.
  12. ^ "Chuan-Pu Lee". Michigan Women Forward. Retrieved 2021-11-12.
  13. ^ "Women's Hall of Fame Center Plans for Picnic". Detroit Free Press. 2001-06-05. p. 29. Retrieved 2021-11-12 – via Newspapers.com.
  14. ^ a b "Dr. Chuan-Pu Lee Obituary (1931 - 2016)". The News Journal. July 31, 2016. Archived from the original on 2021-11-12. Retrieved 2021-11-12.
  15. ^ Mitochondria and microsomes : in honor of Lars Ernster. Reading, Mass.: Addison-Wesley, Advanced Book Program. 1981. ISBN 978-0-201-04576-5 – via Internet Archive.
  16. ^ Membrane bioenergetics : based on the international workshop held at Cranbrook Schools, Bloomfield Hills, Michigan, July 5-7, 1979 in honor of Efraim Racker. Reading, Mass.: Addison-Wesley Pub. Co. 1979. ISBN 978-0-201-03999-3.
  17. ^ Current topics in bioenergetics. Volume 13. Orlando, Florida: Academic Press. 1984. ISBN 978-1-4832-1697-3.
  18. ^ Current topics in bioenergetics. Volume14. Orlando Florida ; London: Academic Press. 1985. ISBN 978-1-4832-1698-0.
  19. ^ Current topics in bioenergetics. V.15. San Diego ; London: Academic P. 1987. ISBN 978-0-12-152515-6.
  20. ^ Lee, C. P. (1991). Current Topics in Bioenergetics. Academic Press. ISBN 978-0-323-15122-1.
  21. ^ Chance, Britton; Lee, Chuan-Pu; Oshino, Reiko; Van Rossum, George D. V. (1964-03-01). "Properties of mitochondria isolated from herring gull salt gland". American Journal of Physiology. Legacy Content. 206 (3): 461–468. doi:10.1152/ajplegacy.1964.206.3.461. ISSN 0002-9513. PMID 14160968.
  22. ^ Lee, Chuan-Pu; Simard-Duquesne, N.; Ernster, L.; Hoberman, H. D. (1965-01-01). "Stereochemistry of hydrogen-transfer in the energy-linked pyridine nucleotide transhydrogenase and related reactions". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation. 105 (3): 397–409. doi:10.1016/S0926-6593(65)80226-0. ISSN 0926-6593. PMID 4379364.
  23. ^ Montal, Maurice; Chance, Britton; Lee, Chuan-pu (December 1970). "Ion transport and energy conservation in submitochondrial particles". The Journal of Membrane Biology. 2 (1): 201–234. doi:10.1007/BF01869861. ISSN 0022-2631. PMID 24174148. S2CID 10575525.
  24. ^ DiMauro, S.; Schotland, D. L.; Bonilla, E.; Lee, C.-P.; Gambetti, P.; Rowland, L. P. (1973-09-01). "Progressive Ophthalmoplegia, Glycogen Storage, and Abnormal Mitochondria". Archives of Neurology. 29 (3): 170–179. doi:10.1001/archneur.1973.00490270052008. ISSN 0003-9942. PMID 4273246.
  25. ^ Schotland, D. L.; DiMauro, S.; Bonilla, E.; Scarpa, A.; Lee, C.-P. (1976-07-01). "Neuromuscular Disorder Associated With a Defect in Mitochondrial Energy Supply". Archives of Neurology. 33 (7): 475–479. doi:10.1001/archneur.1976.00500070017003. ISSN 0003-9942. PMID 180936.
  26. ^ Lee, Chuan-pu (1979). "[12] Tightly coupled beef heart submitochondrial particles". Biomembranes Part F: Bioenergetics: Oxidative Phosphorylation. Methods in Enzymology. Vol. 55. Academic Press. pp. 105–112. doi:10.1016/0076-6879(79)55014-9. ISBN 9780121819552. PMID 222996.
  27. ^ Martens, Margaret E.; Lee, Chuan-Pu (1984-09-15). "Reye's syndrome: Salicylates and mitochondrial functions". Biochemical Pharmacology. 33 (18): 2869–2876. doi:10.1016/0006-2952(84)90209-0. ISSN 0006-2952. PMID 6477646.
  28. ^ Peterson, Patti L.; Martens, Margaret E.; Pu Lee, Chuan (1988-08-01). "Mitochondrial Encephalomyopathies". Neurologic Clinics. Muscle Disease. 6 (3): 529–544. doi:10.1016/S0733-8619(18)30859-4. ISSN 0733-8619. PMID 3065599.
  29. ^ Xiong, Ye; Shie, Feng-Shiun; Zhang, Jing; Lee, Chuan-Pu; Ho, Ye-Shih (2004-05-01). "The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain". Journal of Stroke and Cerebrovascular Diseases. 13 (3): 129–137. doi:10.1016/j.jstrokecerebrovasdis.2004.05.001. ISSN 1052-3057. PMID 17903964.
  30. ^ "Research day in honor of Dr. Chuan-Pu Lee spotlights Wayne's graduate students". School of Medicine News. 2019-03-08. Retrieved 2021-11-13.
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