Chromosome 6 open reading frame 203

MTRES1
Identifiers
Aliases	MTRES1, PRED31, HSPC230, chromosome 6 open reading frame 203, mitochondrial transcription rescue factor 1, C6orf203
External IDs	MGI: 1915101; HomoloGene: 41137; GeneCards: MTRES1; OMA:MTRES1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	107,051,586 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	43,416,990 bp
RNA expression pattern
	Top expressed in
	oocyte; ; tendon of biceps brachii; ; secondary oocyte; ; mucosa of transverse colon; ; biceps brachii; ; vastus lateralis muscle; ; right adrenal gland; ; right adrenal cortex; ; muscle of thigh; ; internal globus pallidus;
	Top expressed in
	motor neuron; ; digastric muscle; ; sternocleidomastoid muscle; ; facial motor nucleus; ; temporal muscle; ; morula; ; triceps brachii muscle; ; intercostal muscle; ; vastus lateralis muscle; ; myocardium of ventricle;
	More reference expression data
	n/a
Orthologs
	51250
	67851
	ENSG00000130349
	ENSMUSG00000019797
	Q9P0P8
	Q9CQF4
	NM_001142468; NM_001142470; NM_016487
	NM_026411
	NP_001135940; NP_001135942; NP_057571
	NP_080687
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. ^[5]

C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.^[6]^[7]

One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.^[7] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130349 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chromosome 6 open reading frame 203". Retrieved 2018-05-11.
^ ^a ^b Gopalakrishna S, Pearce SF, Dinan AM, Schober FA, Cipullo M, Spåhr H, et al. (August 2019). "C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis". Nucleic Acids Research. 47 (17): 9386–9399. doi:10.1093/nar/gkz684. PMC 6755124. PMID 31396629.
^ ^a ^b Kotrys AV, Cysewski D, Czarnomska SD, Pietras Z, Borowski LS, Dziembowski A, Szczesny RJ (June 2019). "Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria". Nucleic Acids Research. 47 (14): 7502–7517. doi:10.1093/nar/gkz542. PMC 6698753. PMID 31226201.

References

Further reading