Christiana Ruhrberg
Christiana Ruhrberg | |
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| Scientific career | |
| Institutions | University College London |
| Thesis | Envoplakin and periplakin, novel components of the cornified envelope and desmosomes. (1997) |
Christiana Ruhrberg is a German-British cell biologist who is Professor of Neuronal and Vascular Biology. University College London[1] She investigates how cells interact during the development of mammals and examines how similar interactions influence the repair and regeneration of adult organs.
Early life and education
[edit]Ruhrberg was an undergraduate student at the Justus-Liebig-Universitaet, where she majored in biology.[2] She was a Master's student at the University of Sussex, where she investigated genetic changes in ovarian cancer.[2] Ruhrberg moved to the Imperial Cancer Research Fund to define the genomic organisation in the human surfeit locus.[2] Ruhrberg was a doctoral researcher at the Imperial Cancer Research Fund, where she worked under the supervision of Fiona Watt.[3][4] In 1986, the British Society for Cell Biology named her Young Cell Biologist of the Year. She received her PhD from Imperial College London in 1997. Ruhrberg was a postdoctoral researcher at the National Institute for Health Research, where she worked under the supervision of Robb Krumlauf to study the development of cranial motor neurons.[5] She returned to the Imperial Cancer Research Fund to work in the laboratory of David Shima, where she investigated molecular mechanisms that underpin the growth of blood vessels.[6]
Research and career
[edit]Ruhrberg moved to University College London in 2003, and was promoted to Professor of Neuronal and Vascular Development at UCL in 2011.[2][7] Here, she has combined her training in neuronal and vascular development to help establish the field of neurovascular co-patterning.[8][9] She also studies how blood vessels grow in the brain and retina (see selected references).
Awards and honours
[edit]- 2003 Werner-Risau-Prize[10]
- 2003 Medical Research Council Career Development Award
- 2018 British Society for Developmental Biology Cheryll Tickle Medal[11]
- 2018 North American Vascular Biology Organization Judah Folkman Award in Vascular Biology[2]
Selected publications
[edit]- Holger Gerhardt; Holger Gerhardt; Matthew Golding; et al. (16 June 2003). "VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia". Journal of Cell Biology. 161 (6): 1163–1177. doi:10.1083/JCB.200302047. ISSN 0021-9525. PMC 2172999. PMID 12810700. Wikidata Q29617501.
- Christiana Ruhrberg; Holger Gerhardt; Holger Gerhardt; et al. (1 October 2002). "Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis". Genes & Development. 16 (20): 2684–2698. doi:10.1101/GAD.242002. ISSN 0890-9369. PMC 187458. PMID 12381667. Wikidata Q35804497.
- Alessandro Fantin; Joaquim M Vieira; Gaia Gestri; et al. (19 April 2010). "Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction". Blood. 116 (5): 829–840. doi:10.1182/BLOOD-2009-12-257832. ISSN 0006-4971. PMC 2938310. PMID 20404134. Wikidata Q30496577.
References
[edit]- ^ "UCL Researcher Profile". 4 October 2024.
- ^ a b c d e "Professor Christiana Ruhrberg wins Judah Folkman Award: vision-research.eu – The Gateway to European Vision Research". www.vision-research.eu. Retrieved 28 May 2021.
- ^ Ruhrberg, Christiana; Hajibagheri, M.A. Nasser; Parry, David A.D.; Watt, Fiona M. (1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". Journal of Cell Biology. 139 (7): 1835–1849. doi:10.1083/jcb.139.7.1835.
- ^ Ruhrberg, C.; Hajibagheri, M. A.; Simon, M.; Dooley, T. P.; Watt, F. M. (1996). "Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin". Journal of Cell Biology. 134 (3): 715–729. doi:10.1083/jcb.134.3.715. PMC 2120946. PMID 8707850.
- ^ Gavalas, Anthony; Ruhrberg, Christiana; Livet, Jean; Henderson, Christopher E.; Krumlauf, Robb (2003). "Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes". Development. 130 (23): 5663–5679. doi:10.1242/dev.00802.
- ^ Lebrasseur, Nicole (2002). "Branching out requires VEGF". The Journal of Cell Biology. 159 (2): 201. doi:10.1083/jcb1592rr1. PMC 2246537.
- ^ "UCL Profiles". ucl.ac.uk.
- ^ Erskine, Lynda; Reijntjes, Susan; Pratt, Thomas; Denti, Laura; Schwarz, Quenten; Vieira, Joaquim M.; Alakakone, Bennett; Shewan, Derryck; Ruhrberg, Christiana (2011). "VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm". Neuron. 70 (5): 951–965. doi:10.1016/j.neuron.2011.02.052.
- ^ Schwarz, Quenten; Gu, Chenghua; Fujisawa, Hajime; Sabelko, Kimberly; Gertsenstein, Marina; Nagy, Andras; Taniguchi, Masahiko; Kolodkin, Alex L.; Ginty, David D.; Shima, David T.; Ruhrberg, Christiana (2004). "Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve". Genes & Development. 18 (22): 2822–2834. doi:10.1101/gad.322904.
- ^ "Laureats". The Werner-Risau-Prize. Retrieved 28 May 2021.
- ^ "The Cheryll Tickle Medal". BSDB – British Society for Developmental Biology. Retrieved 28 May 2021.
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