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Chandan K. Sen

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Professor Chandan K Sen (2023)

Chandan K. Sen is an Indian-American scientist who is known for contributions to the fields of regenerative medicine and wound care. He is currently the Director of the McGowan Institute for Regenerative Medicine of the University of Pittsburgh.[1] He is a University Endowed Professor of Surgery who also serves as the Chief Scientific Officer of wound care services of the University of Pittsburgh Medical Center health system.[2] At the University of Pittsburgh, Professor Sen serves as Associate Vice Chancellor for Life Sciences Innovation and Commercialization.[3] Dr. Sen is the current vice-chair and chair-elect of the National Institute of Health's[4] Diabetic Foot Consortium.[5]

Founded in 1992, McGowan Institute for Regenerative Medicine was initially established as the McGowan Center for Artificial Organ Development. Professor Sen moved with a large team of scientists from Indiana to Pittsburgh in July of 2023.[6] During 2018-2023, Professor Sen served as an Indiana University Distinguished Professor.[7] At Indiana University, Sen directed the Indiana Center for Regenerative Medicine and Engineering (ICRME) and held the J. Stanley Battersby Chair and Distinguished Professor of Surgery.[8] He also served as the Associate Dean of Research as well as Associate Vice President of Research.[9] In 2020, he was awarded the Bicentennial Medal by the University President's Office.[10]

In 2021, Sen was elected to the National Academy of Inventors.[9] Currently, he serves as Editor-in-Chief of Antioxidants & Redox Signaling as well as of Advances in Wound Care.[11] Sen is known for his co-invention of the tissue nanotransfection technology for in vivo tissue reprogramming. His team identified the vasculogenic fibroblasts in humans.[12] His work has included the study of the electroceutical management of infection, and tocotrienol form on natural vitamin E. Sen has an H-index of 116.[13]

Education

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Chandan Sen received his BS and MS from the Rajabazar Science College at Calcutta University where he received his Bachelor of Sciences (Honors in Physiology) in 1987 and his Masters of Science in Human Physiology in 1990.[14]

Sen then moved to Finland for further studies. In 1994, he received his PhD in Physiology from the School of Medicine at the University of Eastern Finland - Kuopio Campus. In January 1995, Sen went to the University of California Berkeley for his postdoctoral studies on redox signaling in the Molecular and Cell Biology department (1995-1996). In 1997, Sen received his first faculty position at the Lawrence Berkeley National Laboratory in Berkeley California.[8]

Career and discoveries

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In 2000, Sen joined The Ohio State University. Here, he was promoted to full professor with tenure in 2004. Later he was recognized with the John H & Mildred C Lumley endowed chair of Surgery.[8] At Ohio State, Sen also served as the Associate Dean of Research.[15] He was the founding Executive Director of the OSU Comprehensive Wound Center, and the founding Director of the OSU Center for Regenerative Medicine & Cell-Based Therapies[16] While at Ohio State, his primary areas of research interest included tissue injury, repair, regeneration, and infection that he studied through his research in stroke, tissue reprogramming, and cutaneous wound healing.[17] This research led to the pioneering of Tissue Nanotransfection (TNT) technology in regenerative medicine. This in vivo tissue reprogramming technology was published in Nature Nanotechnology.[18] The technology won a 2018 Edison Awards for Innovation. [19] Sen’s work has also led to electroceutical management of tissue infection, which received the Frost & Sullivan award for new product innovation.[8] In 2021, Sen was elected Fellow of the National Academy of Inventors. [20]

In 2018 Sen was called “one of the world’s leading experts in the nascent field of regenerative medicine” by the Indianapolis Business Journal after he joined Indiana University as the Director of Indiana Center for Regenerative Medicine and Engineering (ICRME), Executive Director of IU Health Comprehensive Wound Center, J. Stanley Battersby Chair and Professor of Surgery, Associate Vice President of Research, Associate Dean for Entrepreneurial Research.[8] He brought a staff of 30 researchers and $10 million in research grants.[21] Sen is also Professor of Biomedical Engineering by courtesy of the Weldon School of Biomedical Engineering at Purdue University.[22] His research currently focuses on the use of nanotechnology in tissue regeneration.[23]

During the 2020 pandemic, Sen’s work discovered that electrical field can inactive coronavirus and that such approach can be used to develop person protective equipment employing an electroceutical fabric.[24]

Books

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  • Skeletal Muscle Research: Cellular Physiology & Biochemistry (ed. with M. J. Kankaanpää) (1993)
  • Skeletal Muscle Research: Metabolism & Pathophysiology (ed. with L. Packer and O. Hänninen) (1994)
  • Exercise and Oxygen Toxicity (ed. with M. Atalay) (1994)[25]
  • Oxidative Stress In Skeletal Muscles (ed. with Reznick, A et al) (1998)
  • Antioxidant and Redox Regulation of Genes. 2000. doi:10.1016/B978-0-12-636670-9.X5000-4. ISBN 978-0-12-636670-9.
  • Handbook of Oxidants & Antioxidants in Exercise (ed. with L. Packer and O. Hänninen) (2000)
  • Methods in Enzymology: Redox Cell Biology & Genetics - Parts A and B (ed. with L. Packer) (2002)
  • Methods in Enzymology: Oxygen Sensing (ed. with G. L. Semenza) (2004)
  • Advances in Wound Care - Volume 1 (2010)
  • Advances in Wound Care - Volume 2 (2011)
  • Nutrition and Enhanced Sports Performances (ed. with Bagchi D. and Nair S.) (2013)
  • MicroRNA in Regenerative Medicine. 2015. doi:10.1016/C2012-0-02839-6. ISBN 978-0-12-405544-5.

References

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  1. ^ "Chandan Sen taking over as McGowan Institute director". utimes.pitt.edu. 2023-08-23. Retrieved 2023-10-03.
  2. ^ "Pitt and UPMC Recruit Leading Expert in Regenerative Medicine and Wound Care". upmc.com. 2023-05-05. Retrieved 2023-10-03.
  3. ^ "Chandan K. Sen, PhD, MS". health.pitt.ed. Retrieved 2023-10-03.
  4. ^ "First-ever research network tackles diabetic foot complications". nih.gov. 24 July 2020. Retrieved 2024-07-17.
  5. ^ "Diabetic Foot Consortium". diabeticfootconsortium.org. Retrieved 2024-07-17.
  6. ^ "Former top IU med school researcher says why he left". ibj.com. 2023-08-18. Retrieved 2023-10-03.
  7. ^ "Chandan Sen earns IU distinguished professor title". blogs. March 31, 2020.
  8. ^ a b c d e "Chandan K. Sen, PhD". medicine.iu.edu.
  9. ^ a b "Regenerative medicine researcher Chandan Sen, PhD, elected to National Academy of Inventors". medicine.iu.edu. 2021-12-07. Retrieved 2023-10-03.
  10. ^ "Chandan K. Sen". honorsandawards.iu.edu. Retrieved 2023-10-03.
  11. ^ "Advances in Wound Care | Mary Ann Liebert, Inc., publishers". home.liebertpub.com.[non-primary source needed][page needed]
  12. ^ Pal, Durba; Ghatak, Subhadip; Singh, Kanhaiya; Abouhashem, Ahmed Safwat; Kumar, Manishekhar; El Masry, Mohamed S.; Mohanty, Sujit K.; Palakurti, Ravichand; Rustagi, Yashika; Tabasum, Saba; Khona, Dolly K.; Khanna, Savita; Kacar, Sedat; Srivastava, Rajneesh; Bhasme, Pramod; Verma, Sumit S.; Hernandez, Edward; Sharma, Anu; Reese, Diamond; Verma, Priyanka; Ghosh, Nandini; Gorain, Mahadeo; Wan, Jun; Liu, Sheng; Liu, Yunlong; Castro, Natalia Higuita; Gnyawali, Surya C.; Lawrence, William; Moore, Jordan; Perez, Daniel Gallego; Roy, Sashwati; Yoder, Mervin C.; Sen, Chandan K. (28 February 2023). "Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair". Nature Communications. 14 (1): 1129. Bibcode:2023NatCo..14.1129P. doi:10.1038/s41467-023-36665-z. PMC 9975176. PMID 36854749.
  13. ^ "Chandan K Sen - Google Scholar". scholar.google.com.
  14. ^ "CTSI Welcomes New Associate Director for Technology and Innovation".
  15. ^ "OSU center for regenerative studies". /www.bizjournals.com. 2012-04-16. Retrieved 2020-09-07.
  16. ^ "Doctor Chandan Sen uses roots to build Ohio State relations". The Columbus Dispatch.
  17. ^ "Breakthrough device heals organs with a single touch: Device instantly delivers new DNA or RNA into living skin cells to change their function". ScienceDaily.
  18. ^ "Sparking tissue growth, one cell at a time".[unreliable source?]
  19. ^ Awards, Author Edison (April 4, 2018). "Breakthrough Device Looks to Heal Organs". {{cite web}}: |first= has generic name (help)
  20. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2022-11-28. Retrieved 2022-12-19.{{cite web}}: CS1 maint: archived copy as title (link)
  21. ^ Stall, Sam (8 May 2020). "IU team pursuing breathtaking advancements in regenerative medicine".
  22. ^ "People - Biomedical Engineering - Purdue University". Weldon School of Biomedical Engineering - Purdue University.
  23. ^ "IU team pursues regenerative medicine". www.usnews.com. 2020. Retrieved 2020-09-07.
  24. ^ Litke, Eric. "Fact check: Early research shows fabric could neutralize coronaviruses". USA TODAY.
  25. ^ "Trove". trove.nla.gov.au.
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