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Protein-coding gene in the species Homo sapiens
Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q 32.1.[ 5] Serpin A9 is a member of the serpin family of ser ine p rotease in hibitors.
The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies . SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[ 6] [ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: SERPINA9" .
^ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin" . Biochem. J . 405 (3): 489–94. doi :10.1042/BJ20070174 . PMC 2267310 . PMID 17447896 .
^ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas" . Blood . 111 (1): 351–8. doi :10.1182/blood-2007-06-094151 . PMID 17898315 .
^ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas" . Am. J. Clin. Pathol . 130 (1): 117–26. doi :10.1309/9QKE68QU7B825A3U . PMID 18550480 .
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Pan Z, Shen Y, Du C, et al. (2003). "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells" . Am. J. Pathol . 163 (1): 135–44. doi :10.1016/S0002-9440(10)63637-1 . PMC 1868163 . PMID 12819018 .
Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome . 15 (3): 162–78. doi :10.1007/s00335-003-2311-y . PMID 15014966 . S2CID 8594824 .