Catherine J. Wu
Catherine J. Wu | |
|---|---|
| Born | New York City, US |
| Academic background | |
| Education | BS, Harvard College MD, Stanford University School of Medicine |
| Academic work | |
| Institutions | Dana–Farber Cancer Institute Brigham and Women's Hospital |
| Main interests | Chronic lymphocytic leukemia; Cancer |
| Website | wulab |
Catherine J. Wu is an American physician-scientist who studies oncology. She is a Professor of Medicine and Chief of Division of Stem Cell Transplantation and Cellular Therapies at the Dana–Farber Cancer Institute. Her research focuses on longitudinal studies of patients with chronic lymphocytic leukemia (CLL).
Early life and education
[edit]Wu was born in New York City but her family moved to Setauket, New York when she was in grade school. Growing up, she attended Ward Melville High School.[1] She earned her Bachelor of Science degree in Biochemistry (magna cum laude) from Harvard and her Medical degree from Stanford University School of Medicine.[2] Upon completing her medical degree, Wu was trained in internal medicine at Brigham and Women's Hospital and completed her medical fellowship in oncology and hematology at the Dana–Farber Cancer Institute.[1]
Career
[edit]In 2000, Wu joined the Dana-Farber faculty and began her independent research program in 2005.[1]
In 2011, Wu was the recipient of a Stand Up To Cancer Innovative Research Grant for her project "Coupled Genetic and Functional Dissection of Chronic Lymphocytic Leukemia."[3] Using this grant, she identified mutations in the splicing factor SF3B1 connected to the development of chronic lymphocytic leukaemia (CLL).[4] The following year, Wu continued to lead studies on clonal heterogeneity and clonal evolution of CLL and was subsequently elected to the American Society for Clinical Investigation.[5] Wu later led a study analyzing genetic material in CLL and normal tissue of over 500 patients. Her research team identified numerous genetic abnormalities that had the ability to drive leukemia, including RPS15 and IKZF3 which had never before been linked to human cancer.[6]
In 2019, Wu continued her research on patients with chronic lymphocytic leukaemia and led a research study which collaborated with scientists at the Broad Institute, Massachusetts General Hospital, and the University of Washington. They found that genetic changes that occur very early in chronic lymphocytic leukaemia development directly influenced the growth pattern the CLL cells would ultimately take.[7] As a result of her research, she was elected a Member of the National Academy of Medicine.[8] Wu later led a study which uncovered why some patients become resistant to Venclexta, a Leukemia drug. Her research team used leukemia samples from before treatment with venetoclax and following their resistance. They then analyzed the tissue looking for genomic differences in the before and after relapse samples. The results of the analysis were lacking so they performed a large-scale loss-of-function screen to see the effect on other genes. Through this screening, they found that resistant cells make too much MCL1.[9] Using a similar approach, Wu also studies how to implement personalized cancer vaccines by identifying neoantigen targets created by a patient's tumor.[10] This immunotherapeutic effort is applicable to blood and solid tumor malignancies.
References
[edit]- ^ a b c Piana, Ronald (December 10, 2018). "Oncology Researcher Catherine J. Wu, MD, Always Knew She Wanted to Be a Doctor". ascopost.com. Retrieved November 20, 2020.
- ^ "Catherine Wu, M.D." broadinstitute.org. Broad Institute. 29 June 2015. Retrieved November 20, 2020.
- ^ "STAND UP TO CANCER AWARDS NEXT ROUND OF INNOVATIVE RESEARCH GRANTS". standuptocancer.org. April 4, 2011. Retrieved November 21, 2020.
- ^ "Massive DNA search uncovers new mutations driving blood cancer". dana-farber.org. December 12, 2011. Retrieved November 21, 2020.
- ^ "Catherine J. Wu, MD". the-asci.org. Retrieved November 21, 2020.
- ^ "Study charts 'genomic biography' of form of leukemia". dana-farber.org. October 14, 2015. Retrieved November 21, 2020.
- ^ "Patterns of chronic lymphocytic leukemia growth identified". dana-farber.org. May 29, 2019. Retrieved November 21, 2020.
- ^ "Dana–Farber Cancer Institute faculty elected to National Academy of Medicine". dana-farber.org. October 21, 2019. Retrieved November 21, 2020.
- ^ "Resistance to Targeted Leukemia Drug Lurks in Cells' "Powerhouse"". cancerhealth.com. Cancer Health. December 6, 2019. Retrieved November 21, 2020.
- ^ Ott, P. A.; et al. (2017). "An immunogenic personal neoantigen vaccine for patients with melanoma". Nature. 547 (7662): 217–221. Bibcode:2017Natur.547..217O. doi:10.1038/nature22991. PMC 5577644. PMID 28678778.