From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Carboxypeptidase A6 (CPA6 ) is a metallocarboxypeptidase enzyme that in humans is encoded by the CPA6 gene .[ 5] olfactory bulb and is broadly expressed in the embryonic brain and other tissues.[ 6]
The protein encoded by this gene belongs to the family of carboxypeptidases , which catalyze the release of C-terminal amino acid , and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides . Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome .[ 5]
CPA6 processes several neuropeptides , including [Met]- and [Leu]-enkephalin , angiotensin I , and neurotensin in vitro.[ 6] enkephalins and neurotensin into inactive forms, it can convert the inactive angiotensin I into the active angiotensin II .[ 6] in vivo , but the nature of these substrates and the effects of these cleavages are currently unknown.
Wei, S.; Segura, S.; Vendrell, J.; Aviles, F. X.; Lanoue, E.; Day, R.; Feng, Y.; Fricker, L. D. (2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family" . The Journal of Biological Chemistry . 277 (17): 14954–14964. doi :10.1074/jbc.M112254200 PMID 11836249 . Pizzuti, A.; Calabrese, G.; Bozzali, M.; Telvi, L.; Morizio, E.; Guida, V.; Gatta, V.; Stuppia, L.; Ion, A.; Palka, G.; Dallapiccola, B. (2002). "A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient". Investigative Ophthalmology & Visual Science . 43 (12): 3609–3612. PMID 12454025 . Lyons, P. J.; Callaway, M. B.; Fricker, L. D. (2008). "Characterization of Carboxypeptidase A6, an Extracellular Matrix Peptidase" . Journal of Biological Chemistry . 283 (11): 7054–7063. doi :10.1074/jbc.M707680200 PMID 18178555 . Sharif, S. A.; Du, X.; Myles, T.; Song, J. J.; Price, E.; Lee, D. M.; Goodman, S. B.; Nagashima, M.; Morser, J.; Robinson, W. H.; Leung, L. L. K. (2009). "Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis" . Arthritis & Rheumatism . 60 (10): 2902–2912. doi :10.1002/art.24814 . PMC 3757557 PMID 19790060 . Lyons, P. J.; Fricker, L. D. (2010). "Substrate Specificity of Human Carboxypeptidase A6" . Journal of Biological Chemistry . 285 (49): 38234–38242. doi :10.1074/jbc.M110.158626 PMC 2992257 PMID 20855895 .
