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Enzyme found in humans
Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene .[ 5] [ 6]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.[ 6]
In melanocytic cells CA14 gene expression may be regulated by MITF .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000118298 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038526 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Nov 1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1". Genomics . 61 (1): 74–81. doi :10.1006/geno.1999.5938 . PMID 10512682 . ^ a b "Entrez Gene: CA14 carbonic anhydrase XIV" .^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x PMID 19067971 .
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