CTF8

CHTF8
Identifiers
Aliases	CHTF8, CTF8, DERPC, chromosome transmission fidelity factor 8
External IDs	OMIM: 613202; MGI: 2443370; HomoloGene: 84588; GeneCards: CHTF8; OMA:CHTF8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 69,118,010 bp End 69,132,588 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 107,610,495 bp End 107,620,233 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte human kidney mucosa of transverse colon apex of heart monocyte islet of Langerhans right lobe of liver smooth muscle tissue right lobe of thyroid gland uterine tube Top expressed in yolk sac tail of embryo ventricular zone thymus lip lens lung genital tubercle neural layer of retina spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA clamp loader activity single-stranded DNA helicase activity Cellular component nucleus extracellular exosome nucleoplasm Ctf18 RFC-like complex Biological process mitotic sister chromatid cohesion DNA replication cell cycle positive regulation of DNA-directed DNA polymerase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54921 214987 Ensembl ENSG00000168802 ENSMUSG00000046691 UniProt P0CG12 P0CG13 P0CG14 P0CG15 RefSeq (mRNA) NM_001039690 NM_001040145 NM_001040146 NM_017804 NM_145412 NM_001364186 RefSeq (protein) NP_001034779 NP_001035236 NP_001034779.1 NP_001035236.1 NP_663387 NP_001351115 NP_663387.3 Location (UCSC) Chr 16: 69.12 – 69.13 Mb Chr 8: 107.61 – 107.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene.

This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair.

This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternative splicing results in multiple variants encoding different isoforms. This gene has a pseudogene on chromosome X.

External links

• Human CHTF8 genome location and CHTF8 gene details page in the UCSC Genome Browser.

Further reading

• Mayer ML, Gygi SP, Aebersold R, Hieter P (2001). "Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae". Mol. Cell. 7 (5): 959–70. doi:10.1016/S1097-2765(01)00254-4. PMID 11389843.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sun M, Ma L, Xu L, et al. (2004). "A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors". Mol. Med. 8 (10): 655–63. doi:10.1007/BF03402176. PMC 2039945. PMID 12477976.
• Bermudez VP, Maniwa Y, Tappin I, et al. (2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.