CTDNEP1

CTDNEP1
Identifiers
Aliases	CTDNEP1, DULLARD, HSA011916, NET56, CTD nuclear envelope phosphatase 1
External IDs	OMIM: 610684; MGI: 1914431; HomoloGene: 9100; GeneCards: CTDNEP1; OMA:CTDNEP1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,881,427 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; ganglionic eminence; ; stromal cell of endometrium; ; skin of abdomen; ; canal of the cervix; ; spleen; ; smooth muscle tissue; ; lymph node; ; uterine tube;
	Top expressed in
	muscle of thigh; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; skeletal muscle tissue; ; tail of embryo; ; ventricular zone; ; ankle; ; genital tubercle; ; superior frontal gyrus; ; upper arm;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein serine/threonine phosphatase activity; protein binding; hydrolase activity;
Cellular component	cytoplasm; integral component of membrane; nuclear membrane; nuclear envelope; endoplasmic reticulum membrane; membrane; Nem1-Spo7 phosphatase complex; endoplasmic reticulum; nucleus; lipid droplet;
Biological process	positive regulation of triglyceride biosynthetic process; nuclear envelope organization; positive regulation of canonical Wnt signaling pathway; protein dephosphorylation; gamete generation; mitotic nuclear membrane disassembly; protein localization to nucleus; mesoderm development; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23399
	67181
	n/a
	ENSMUSG00000018559
	O95476
	Q3TP92
	NM_015343; NM_001143775
	NM_026017
	NP_001137247; NP_056158
	NP_080293
	Wikidata
View/Edit Human	View/Edit Mouse

In cell biology, CTDNEP1 (CTD nuclear envelope phosphatase 1) is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus. The gene promotes neural development by inhibiting bone morphogenetic proteins (BMPs). The encoded protein is relatively small and only contains 244 amino acids.

Description

CTDnep1, which stands for CTD nuclear envelope phosphatase 1. It is a protein coding gene, which include phosphatase activity and protein serine/threonine phosphatase activity. CTDnep1 encodes a protein serine/threonine phosphatase and dephosphorylates LPIN1 and LPIN2. LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglycerol. The reaction can affect and change the lipid concentration of the endoplasmic reticulum and the nucleus.

Dullard and BNP signaling

Neural development happens in the dorsal ectoderm. In the genus Xenopus, over expression of CTDNEP1 undergoes apoptosis in early development. CTDNEP1 helps promote Ubiquitin by proteosomal degradation. CTDNEP1 mRNA is derived from maternal genes and is localized within the animal neural hemisphere. Functioning negatively for the regulation of Bone Morphogenetic Proteins (BMPs), CTDNEP1 conserves the C-terminal region of NLI-IF, in which is fairly dominant in cellular functions. CTDNEP1 is essential for inhibiting BMP receptor activation during Xenopus neuralization.

Human Dullard

Human CTDNEP1 has shown that the protein has two membrane spanning regions. One end is the N-terminal end, which helps localize the protein to the nuclear envelope. CTDNEP1 dephosphorylates the mammalian phosphatidic acid phosphatase, lipin. CTDNEP1 participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and that this cascade is conserved from yeast to mammals. There is belief that CTDNEP1 may have other targets that is not only associated with the nuclear envelope. In recent studies, CTDNEP1 interacts with BMP type 1 to inhibit dependent phosphorylation. This can conclude that it is a potential source for regulating the level of BMP signaling and can affect germ cell specification.

CTD nuclear envelope phosphatase 1 is a protein in humans that is encoded by the CTDNEP1 gene. ^[4]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018559 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CTD nuclear envelope phosphatase 1". Retrieved 2012-12-07.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000018559 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CTD nuclear envelope phosphatase 1". Retrieved 2012-12-07.

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