CRIP2

CRIP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CU8
Identifiers
Aliases	CRIP2, CRIP, CRP2, ESP1, cysteine rich protein 2
External IDs	OMIM: 601183; MGI: 1915587; HomoloGene: 135666; GeneCards: CRIP2; OMA:CRIP2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	105,480,162 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	113,109,126 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; right uterine tube; ; left ventricle;
	Top expressed in
	ankle joint; ; right ventricle; ; right lung; ; right lung lobe; ; left lung; ; gastrula; ; interventricular septum; ; endothelial cell of lymphatic vessel; ; lip; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; zinc ion binding; protein binding;
Cellular component	cell cortex;
Biological process	positive regulation of cell population proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	1397
	68337
	ENSG00000182809
	ENSMUSG00000006356
	P52943
	Q9DCT8
	NM_001270837; NM_001270841; NM_001312
	NM_024223; NM_001347443
	NP_001257766; NP_001257770; NP_001303
	NP_001334372; NP_077185
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.^[5]^[6]^[7]^[8]

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182809 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006356 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. doi:10.1080/15216549600201831. PMID 8843343. S2CID 25981657.
^ Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
^ Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.
^ "Entrez Gene: CRIP2 cysteine-rich protein 2".
^ Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.

External links

Human CRIP2 genome location and CRIP2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
van Ham M, Croes H, Schepens J, et al. (2004). "Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL". Genes Cells. 8 (7): 631–44. doi:10.1046/j.1365-2443.2003.00660.x. PMID 12839623.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182809 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006356 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8843343-5] Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. doi:10.1080/15216549600201831. PMID 8843343. S2CID 25981657.

[pmid8824798-6] Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.

[pmid10681529-7] Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.

[entrez-8] "Entrez Gene: CRIP2 cysteine-rich protein 2".

[pmid12530967-9] Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.

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References

External links

Further reading