CRIM1

CRIM1
Identifiers
Aliases	CRIM1, CRIM-1, S52, cysteine rich transmembrane BMP regulator 1 (chordin-like), cysteine rich transmembrane BMP regulator 1
External IDs	OMIM: 606189; MGI: 1354756; HomoloGene: 9510; GeneCards: CRIM1; OMA:CRIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	36,551,135 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	78,684,021 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; renal medulla; ; superficial temporal artery; ; lactiferous duct; ; pericardium; ; glomerulus; ; germinal epithelium; ; metanephric glomerulus; ; urethra; ; vena cava;
	Top expressed in
	retinal pigment epithelium; ; epithelium of lens; ; decidua; ; gastrula; ; vestibular membrane of cochlear duct; ; lateral geniculate nucleus; ; medial dorsal nucleus; ; intercostal muscle; ; medial geniculate nucleus; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; PDZ domain binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; serine-type endopeptidase inhibitor activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; membrane;
Biological process	negative regulation of catalytic activity; regulation of cell growth; nervous system development; negative regulation of endopeptidase activity; insulin-like growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	51232
	50766
	ENSG00000277354; ENSG00000150938
	ENSMUSG00000024074
	Q9NZV1
	Q9JLL0
	NM_016441
	NM_015800
	NP_057525
	NP_056615
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine-rich motor neuron 1 protein is a protein that in humans is encoded by the CRIM1 gene.^[5]^[6]

Function

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival.^[5]^[6]

Clinical significance

Loss of Crim1 function as demonstrated by the Crim1 KST264 hypomorph mice resulted in onset of chronic kidney disease with accompanying pathology including papillary hypoplasia, functional urinary tract obstruction, ectopic collagen accumulation within the endothelium and tubulointerstitial fibrosis which was in part attributed by (endothelial) epithelial–mesenchymal transition.^[7]^[8]

References

^ ^a ^b ^c ENSG00000150938 GRCh38: Ensembl release 89: ENSG00000277354, ENSG00000150938 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024074 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Kolle G, Georgas K, Holmes GP, Little MH, Yamada T (Feb 2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mechanisms of Development. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437. S2CID 6529349.
^ ^a ^b "Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)".
^ Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L (Apr 2013). "Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins". The Journal of Pathology. 229 (5): 685–96. doi:10.1002/path.4155. PMID 23224993. S2CID 22837861.
^ Wilkinson L, Kurniawan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH (Aug 2012). "Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice" (PDF). The Journal of Pathology. 227 (4): 499–510. doi:10.1002/path.4036. PMID 22488641. S2CID 2777257.

External links

Human CRIM1 genome location and CRIM1 gene details page in the UCSC Genome Browser.

Wilkinson L, Kurniawan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH (Aug 2012). "Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice" (PDF). The Journal of Pathology. 227 (4): 499–510. doi:10.1002/path.4036. PMID 22488641. S2CID 2777257.
Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L (Apr 2013). "Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins". The Journal of Pathology. 229 (5): 685–96. doi:10.1002/path.4155. PMID 23224993. S2CID 22837861.
Pennisi DJ, Wilkinson L, Kolle G, Sohaskey ML, Gillinder K, Piper MJ, McAvoy JW, Lovicu FJ, Little MH (Feb 2007). "Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems". Developmental Dynamics. 236 (2): 502–11. doi:10.1002/dvdy.21015. PMID 17106887. S2CID 1563138.
Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Wilkinson L, Kolle G, Wen D, Piper M, Scott J, Little M (Sep 2003). "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface". The Journal of Biological Chemistry. 278 (36): 34181–8. doi:10.1074/jbc.M301247200. PMID 12805376.
Glienke J, Sturz A, Menrad A, Thierauch KH (Dec 2002). "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo". Mechanisms of Development. 119 (2): 165–75. doi:10.1016/S0925-4773(02)00355-6. PMID 12464430. S2CID 7308653.
Georgas K, Bowles J, Yamada T, Koopman P, Little MH (Dec 2000). "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern". Developmental Dynamics. 219 (4): 582–7. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I. PMID 11084657.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000150938 GRCh38: Ensembl release 89: ENSG00000277354, ENSG00000150938 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024074 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10642437-5] Kolle G, Georgas K, Holmes GP, Little MH, Yamada T (Feb 2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mechanisms of Development. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437. S2CID 6529349.

[entrez-6] "Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)".

[7] Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L (Apr 2013). "Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins". The Journal of Pathology. 229 (5): 685–96. doi:10.1002/path.4155. PMID 23224993. S2CID 22837861.

[8] Wilkinson L, Kurniawan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH (Aug 2012). "Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice" (PDF). The Journal of Pathology. 227 (4): 499–510. doi:10.1002/path.4036. PMID 22488641. S2CID 2777257.

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Function

Clinical significance

References

External links

Further reading