COX6C

COX6C
Identifiers
Aliases	COX6C, cytochrome c oxidase subunit 6C
External IDs	OMIM: 124090; HomoloGene: 136781; GeneCards: COX6C; OMA:COX6C - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	99,893,707 bp
RNA expression pattern
	Top expressed in
	pons; ; ventricle; ; left ventricle; ; body of tongue; ; right ventricle; ; superior vestibular nucleus; ; Skeletal muscle tissue of rectus abdominis; ; apex of heart; ; biceps brachii; ; right auricle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytochrome-c oxidase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion;
Biological process	proton transmembrane transport; generation of precursor metabolites and energy; electron transport chain; mitochondrial electron transport, cytochrome c to oxygen;
	Sources:Amigo / QuickGO
Orthologs
	1345
	102640946
	ENSG00000164919
	n/a
	P09669
	n/a
	NM_004374
	n/a
	NP_004365
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.^[4]^[5]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.
^ ^a ^b "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".

External links

Human COX6C genome location and COX6C gene details page in the UCSC Genome Browser.

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. S2CID 2286919.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kish SJ, Mastrogiacomo F, Guttman M, et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. doi:10.1046/j.1471-4159.1999.0720700.x. PMID 9930743. S2CID 32587972.
Wang FL, Wang Y, Wong WK, et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma". Cancer Res. 56 (16): 3634–7. PMID 8705997.
Otsuka M, Mizuno Y, Yoshida M, et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc". Nucleic Acids Res. 16 (22): 10916. doi:10.1093/nar/16.22.10916. PMC 338951. PMID 2849755.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164919 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072584-4] Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.

[entrez-5] "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".

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References

External links

Further reading