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Protein-coding gene in humans
Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene .[ 5] [ 6] [ 7]
CLNS1A has been shown to interact with:
^ a b c GRCh38: Ensembl release 89: ENSG00000074201 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025439 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun . 208 (1): 89–95. doi :10.1006/bbrc.1995.1309 . PMID 7887970 . ^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics . 38 (3): 438–41. doi :10.1006/geno.1996.0651 . PMID 8975725 . ^ "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A" .^ Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation" . J. Biol. Chem . 279 (26): 27286–93. doi :10.1074/jbc.M402159200 PMID 15075326 . ^ a b c Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J , Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Mol. Cell. Biol . 21 (24): 8289–300. doi :10.1128/MCB.21.24.8289-8300.2001 . PMC 99994 PMID 11713266 . ^ Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (May 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology" . J. Biol. Chem . 273 (18): 10811–4. doi :10.1074/jbc.273.18.10811 PMID 9556550 . ^ Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins" . J. Biol. Chem . 277 (10): 8243–7. doi :10.1074/jbc.M109984200 PMID 11756452 . ^ Krzyzanowski A, Gasper R, Adihou H, 't Hart P, Waldmann H (Feb 2021). "Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex" . ChemBioChem . 22 (11): 1908–1914. doi :10.1002/cbic.202100079 PMC 8252068 PMID 33624332 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
