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CLIC4

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CLIC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDsOMIM: 606536; MGI: 1352754; HomoloGene: 8490; GeneCards: CLIC4; OMA:CLIC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013943

NM_013885

RefSeq (protein)

NP_039234

NP_038913

Location (UCSC)Chr 1: 24.75 – 24.84 MbChr 4: 134.94 – 135 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.[5]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).[5]

Binding partners

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CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169504Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037242Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CLIC4 chloride intracellular channel 4".
  6. ^ Suginta W, Karoulias N, Aitken A, Ashley RH (October 2001). "Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms". Biochem. J. 359 (Pt1): 55–64. doi:10.1042/0264-6021:3590055. PMC 1222121. PMID 11563969.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.