CLEC3B

CLEC3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HTN, 1RJH, 1TN3, 3L9J
Identifiers
Aliases	CLEC3B, TN, TNA, C-type lectin domain family 3 member B
External IDs	OMIM: 187520; MGI: 104540; HomoloGene: 31145; GeneCards: CLEC3B; OMA:CLEC3B - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 45,001,548 bp End 45,036,071 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F4|9 73.91 cM Start 122,980,011 bp End 122,986,497 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue apex of heart right auricle tibial nerve right lung placenta spleen right testis right coronary artery upper lobe of left lung Top expressed in lip ankle esophagus muscle of thigh skin of external ear ankle joint right lung right lung lobe intercostal muscle left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding heparin binding kringle domain binding carbohydrate binding Cellular component cytoplasm extracellular matrix extracellular exosome granular component platelet dense granule lumen extracellular space extracellular region collagen-containing extracellular matrix Biological process cellular response to organic substance bone mineralization cellular response to transforming growth factor beta stimulus positive regulation of plasminogen activation ossification platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7123 21922 Ensembl ENSG00000163815 ENSMUSG00000025784 UniProt P05452 P43025 Q8CFZ6 RefSeq (mRNA) NM_001308394 NM_003278 NM_011606 RefSeq (protein) NP_001295323 NP_003269 NP_035736 Location (UCSC) Chr 3: 45 – 45.04 Mb Chr 9: 122.98 – 122.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tetranectin is a protein that in humans is encoded by the CLEC3B gene.

External links

• Human CLEC3B genome location and CLEC3B gene details page in the UCSC Genome Browser.

Further reading

• Wewer UM, Albrechtsen R (1992). "Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer". Lab. Invest. 67 (2): 253–62. PMID 1354271.
• Berglund L, Petersen TE (1992). "The gene structure of tetranectin, a plasminogen binding protein". FEBS Lett. 309 (1): 15–9. doi:10.1016/0014-5793(92)80729-Z. PMID 1511740. S2CID 35630722.
• Borregaard N, Christensen L, Bejerrum OW, et al. (1990). "Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase". J. Clin. Invest. 85 (2): 408–16. doi:10.1172/JCI114453. PMC 296439. PMID 2298916.
• Clemmensen I (1990). "Interaction of tetranectin with sulphated polysaccharides and trypan blue". Scand. J. Clin. Lab. Invest. 49 (8): 719–25. doi:10.3109/00365518909091550. PMID 2533389.
• Clemmensen I, Petersen LC, Kluft C (1986). "Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma: tetranectin". Eur. J. Biochem. 156 (2): 327–33. doi:10.1111/j.1432-1033.1986.tb09586.x. PMID 3009181.
• Fuhlendorff J, Clemmensen I, Magnusson S (1988). "Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein". Biochemistry. 26 (21): 6757–64. doi:10.1021/bi00395a027. PMID 3427041.
• Wewer UM, Ibaraki K, Schjørring P, et al. (1995). "A potential role for tetranectin in mineralization during osteogenesis". J. Cell Biol. 127 (6 Pt 1): 1767–75. doi:10.1083/jcb.127.6.1767. PMC 2120295. PMID 7798325.
• Nielsen H, Clemmensen I, Kharazmi A (1993). "Tetranectin: a novel secretory protein from human monocytes". Scand. J. Immunol. 37 (1): 39–42. doi:10.1111/j.1365-3083.1993.tb01662.x. PMID 8418471. S2CID 6469331.
• Durkin ME, Naylor SL, Albrechtsen R, Wewer UM (1997). "Assignment of the gene for human tetranectin (TNA) to chromosome 3p22→p21.3 by somatic cell hybrid mapping". Cytogenet. Cell Genet. 76 (1–2): 39–40. doi:10.1159/000134509. PMID 9154122.
• Nielsen BB, Kastrup JS, Rasmussen H, et al. (1997). "Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil". FEBS Lett. 412 (2): 388–96. doi:10.1016/S0014-5793(97)00664-9. PMID 9256258. S2CID 9290914.
• Kastrup JS, Nielsen BB, Rasmussen H, et al. (1998). "Structure of the C-type lectin carbohydrate recognition domain of human tetranectin". Acta Crystallogr. D. 54 (Pt 5): 757–66. Bibcode:1998AcCrD..54..757K. doi:10.1107/S0907444997016806. PMID 9757090.
• Jaquinod M, Holtet TL, Etzerodt M, et al. (2000). "Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin". Biol. Chem. 380 (11): 1307–14. doi:10.1515/BC.1999.166. PMID 10614823. S2CID 9060086.
• Lorentsen RH, Graversen JH, Caterer NR, et al. (2000). "The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain". Biochem. J. 347. Pt 1 (1): 83–7. doi:10.1042/0264-6021:3470083. PMC 1220934. PMID 10727405.
• Graversen JH, Jacobsen C, Sigurskjold BW, et al. (2001). "Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold". J. Biol. Chem. 275 (48): 37390–6. doi:10.1074/jbc.M004873200. PMID 10964919.
• Arvanitis DL, Kamper EF, Kopeikina L, et al. (2002). "Tetranectin expression in gastric adenocarcinomas". Histol. Histopathol. 17 (2): 471–5. PMID 11962752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Westergaard UB, Andersen MH, Heegaard CW, et al. (2003). "Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator". Eur. J. Biochem. 270 (8): 1850–4. doi:10.1046/j.1432-1033.2003.03549.x. PMID 12694198.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hermann M, Pirkebner D, Draxl A, et al. (2005). "In the search of potential human islet stem cells: is tetranectin showing us the way?". Transplant. Proc. 37 (2): 1322–5. doi:10.1016/j.transproceed.2004.12.050. PMID 15848710.