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CLDN18

From Wikipedia, the free encyclopedia
CLDN18
Identifiers
AliasesCLDN18, SFTA5, SFTPJ, claudin 18
External IDsOMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016369
NM_001002026

NM_001194921
NM_001194922
NM_001194923
NM_019815

RefSeq (protein)

NP_001002026
NP_057453

NP_001181850
NP_001181851
NP_001181852
NP_062789

Location (UCSC)Chr 3: 138 – 138.03 MbChr 9: 99.57 – 99.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[5] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[6] [supplied by OMIM][5]

Clinical significance

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Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[7]

Zolbetuximab targets Claudin 18.2 to help treat gastric cancers.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066405Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032473Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CLDN18 claudin 18".
  6. ^ Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
  7. ^ Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
  8. ^ "Astellas' VYLOY™ (zolbetuximab) Approved in Japan for Treatment of Gastric Cancer". www.prnewswire.com. 2024-03-26. Retrieved 2024-09-29.
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Further reading

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