CENTG1

AGAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BMJ, 2IWR, 2RLO
Identifiers
Aliases	AGAP2, CENTG1, GGAP2, PIKE, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
External IDs	OMIM: 605476; MGI: 3580016; HomoloGene: 86815; GeneCards: AGAP2; OMA:AGAP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q14.1 Start 57,723,761 bp End 57,742,157 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 126,911,153 bp End 126,929,038 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe cingulate gyrus anterior cingulate cortex nucleus accumbens amygdala prefrontal cortex caudate nucleus Brodmann area 9 putamen Top expressed in striatum of neuraxis superior frontal gyrus primary visual cortex hippocampus proper olfactory bulb dentate gyrus of hippocampal formation granule cell cerebellar cortex hypothalamus granulocyte thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity metal ion binding nucleotide binding GTP binding protein binding GTPase activity Cellular component extracellular exosome membrane nucleolus cytoplasm mitochondrion nucleus Biological process negative regulation of neuron apoptotic process protein transport negative regulation of protein catabolic process positive regulation of GTPase activity transport positive regulation of 1-phosphatidylinositol-3-kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116986 216439 Ensembl ENSG00000135439 ENSMUSG00000025422 UniProt Q99490 Q3UHD9 RefSeq (mRNA) NM_001122772 NM_014770 NM_001033263 NM_001301014 RefSeq (protein) NP_001116244 NP_055585 NP_001028435 NP_001287943 Location (UCSC) Chr 12: 57.72 – 57.74 Mb Chr 10: 126.91 – 126.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.

Interactions

CENTG1 has been shown to interact with:

• EPB41L1,
• HOMER1 and
• PIK3R1.

External links

• Human AGAP2 genome location and AGAP2 gene details page in the UCSC Genome Browser.

Further reading

• Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
• Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell. 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977. S2CID 16610638.
• Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature. 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862. S2CID 4371421.
• Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J, Randazzo PA (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
• Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
• Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310. S2CID 807407.
• Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
• Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. Bibcode:2004PNAS..101.6993A. doi:10.1073/pnas.0400921101. PMC 406454. PMID 15118108.
• Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". J. Cell Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
• Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119. S2CID 21766234.
• Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930.
• Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
• Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848. PMID 17037982.
• Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107.
• Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440. S2CID 1156814.
• Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797. S2CID 28218061.