CDCA7

CDCA7
Identifiers
Aliases	CDCA7, JPO1, ICF3, cell division cycle associated 7
External IDs	OMIM: 609937; MGI: 1914203; HomoloGene: 49970; GeneCards: CDCA7; OMA:CDCA7 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	173,368,997 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	72,317,237 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; ventricular zone; ; ganglionic eminence; ; thymus; ; rectum; ; mucosa of sigmoid colon; ; gonad; ; duodenum; ; jejunal mucosa; ; pylorus;
	Top expressed in
	ventricular zone; ; thymus; ; epiblast; ; medial ganglionic eminence; ; tail of embryo; ; hand; ; primitive streak; ; embryo; ; mandibular prominence; ; abdominal wall;
	More reference expression data
	n/a
Orthologs
	83879
	66953
	ENSG00000144354
	ENSMUSG00000055612
	Q9BWT1
	Q9D0M2
	NM_031942; NM_145810
	NM_025866
	NP_114148; NP_665809
	NP_080142
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene.^[5]^[6]^[7]

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144354 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.
^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
^ ^a ^b "Entrez Gene: CDCA7 cell division cycle associated 7".

External links

Human CDCA7 genome location and CDCA7 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Osthus RC, Karim B, Prescott JE, et al. (2005). "The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo". Cancer Res. 65 (13): 5620–7. doi:10.1158/0008-5472.CAN-05-0536. PMC 1224734. PMID 15994934.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Goto Y, Hayashi R, Muramatsu T, et al. (2006). "JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity". Biochim. Biophys. Acta. 1759 (1–2): 60–8. doi:10.1016/j.bbaexp.2006.02.004. PMID 16580749.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144354 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055612 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11598121-5] Prescott JE, Osthus RC, Lee LA, Lewis BC, Shim H, Barrett JF, Guo Q, Hawkins AL, Griffin CA, Dang CV (Dec 2001). "A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation". J Biol Chem. 276 (51): 48276–84. doi:10.1074/jbc.M107357200. PMID 11598121.

[pmid12188893-6] Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.

[entrez-7] "Entrez Gene: CDCA7 cell division cycle associated 7".

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References

External links

Further reading