CD300LB (gene)

CD300LB
Identifiers
Aliases	CD300LB, CD300b, CLM-7, CLM7, CMRF35-A2, IREM-3, IREM3, TREM-5, TREM5, CD300 molecule like family member b
External IDs	OMIM: 610705; MGI: 2685099; HomoloGene: 18374; GeneCards: CD300LB; OMA:CD300LB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,531,475 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,825,212 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; appendix; ; bone marrow cells; ; testicle; ; gallbladder; ; spleen; ; right lung; ; smooth muscle tissue;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; blood; ; calvaria; ; spleen; ; sciatic nerve; ; embryo; ; blastocyst; ; lumbar subsegment of spinal cord; ; mesenteric lymph nodes;
	More reference expression data
	n/a
Orthologs
	124599
	217304
	ENSG00000178789
	ENSMUSG00000063193
	A8K4G0
	Q3U497
	NM_174892
	NM_001037138; NM_199221; NM_001347651
	NP_777552
	NP_001334580; NP_954691
	Wikidata
View/Edit Human	View/Edit Mouse

CD300 molecule like family member b is a protein that in humans is encoded by the CD300LB gene. ^[5]

Function

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178789 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD300 molecule like family member b". Retrieved 2018-07-19.

Martínez-Barriocanal A, Sayós J (September 2006). "Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways". J. Immunol. 177 (5): 2819–30. doi:10.4049/jimmunol.177.5.2819. PMID 16920917.
Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T (January 2008). "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells". Blood. 111 (2): 688–98. doi:10.1182/blood-2007-04-085787. PMID 17928527.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Gasiorowski RE, Ju X, Hart DN, Clark GJ (January 2013). "CD300 molecule regulation of human dendritic cell functions". Immunol. Lett. 149 (1–2): 93–100. doi:10.1016/j.imlet.2012.10.005. PMID 23072861.
Voss OH, Murakami Y, Pena MY, Lee HN, Tian L, Margulies DH, Street JM, Yuen PS, Qi CF, Krzewski K, Coligan JE (June 2016). "Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock". Immunity. 44 (6): 1365–78. doi:10.1016/j.immuni.2016.05.005. PMC 4917413. PMID 27261276.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178789 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD300 molecule like family member b". Retrieved 2018-07-19.

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Function

References

Further reading