Founded in 1964 as Juventud Antoniana, the club first reached Tercera División in the 1987–88 season, achieving an impressive fifth position. In that year, however, the club merged with UB Lebrijana to create CD Lebrija, in order to strengthen football in the city.[2]
In 1994, as the merger was undone, Antoniano was refounded, and returned to the fourth division in 2001.