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Protein-coding gene in the species Homo sapiens
Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene .[ 5] [ 6] [ 7]
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB ; MIM 164011) activity through the IKK (e.g., IKBKB ; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM][ 7]
CARD10 has been shown to interact with BCL10 .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000100065 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033170 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B" . J. Biol. Chem . 276 (24): 21405–9. doi :10.1074/jbc.M102488200 PMID 11259443 . ^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation" . FEBS Lett . 496 (2–3): 121–7. doi :10.1016/S0014-5793(01)02414-0 PMID 11356195 . ^ a b "Entrez Gene: CARD10 caspase recruitment domain family, member 10" .^ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B" . J. Biol. Chem . 276 (24): 21405–9. doi :10.1074/jbc.M102488200 PMID 11259443 .
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