Mangostin
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| Names | |
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| Preferred IUPAC name
1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | |
| Other names
alpha-mangostin
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.208.637 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C24H26O6 | |
| Molar mass | 410.466 g·mol−1 |
| Appearance | Yellow crystalline solid |
| Density | 1.265 g/ml |
| Melting point | 182 °C (360 °F; 455 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure.
Source
[edit]The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted the optimization steps in order to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and was able to achieve 9.2 g/kg DW.[1] The rind of fully ripe fruits also contains the xanthonoids gartanin, 8-disoxygartanin, and normangostin.[citation needed]
Research
[edit]Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.[2]
In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.[3][better source needed]
Related compounds
[edit]A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.[citation needed]
References
[edit]- ^ Khaw, Kooi Yeong; Ong, Yong Sze; Goh, Bey-Hing (2020). "A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin". Progress in Drug Discovery & Biomedical Science. 3 (1). doi:10.36877/pddbs.a0000072.
- ^ Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.
- ^ Shankaranarayan D, Gopalakrishnan C, Kameswaran L (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.