Bromal hydrate

Bromal hydrate
Names
	IUPAC name 2,2,2-Tribromo-1,1-ethanediol
	Other names tribromoethylidene glycol
Identifiers
CAS Number	507-42-6;
3D model (JSmol)	Interactive image;
ChemSpider	61488;
ECHA InfoCard	100.007.340
EC Number	208-073-2;
PubChem CID	68181;
UNII	BQU83Q7216;
CompTox Dashboard (EPA)	DTXSID20198751 ;
	InChI InChI=1S/C2H3Br3O2/c3-2(4,5)1(6)7/h1,6-7H Key: NJHVMXFNIZTTBV-UHFFFAOYSA-N;
	SMILES C(C(Br)(Br)Br)(O)O;
Properties
Chemical formula	C2H3Br3O2
Molar mass	298.756 g·mol−1
Appearance	white crystalline solid with bromal-like smell and taste
Melting point	53.5 °C (128.3 °F; 326.6 K)
Solubility in water	Soluble
Solubility	Soluble in ethanol, Diethyl ether, chloroform and Glycerin
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H315, H319, H335
Precautionary statements	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Bromal hydrate is an organobromine compound with the chemical formula C₂H₃Br₃O₂. It is the bromine analogue of chloral hydrate. Bromal hydrate forms when bromal is reacted with water. It decomposes to bromal and water upon distillation.^[1] It has hypnotic and analgesic properties but acts like a stimulant at lower doses.^[3] Bromal hydrate is more physiologically active than its chlorine analogue, chloral hydrate.^[4] Its direct effect on the heart muscles is stronger than that of chloral hydrate.^[3] Its analgesic effects were attributed to the proposed metabolism to bromoform.^[5]

It was also tried as a medication for epilepsy, but was found ineffective.^[1]

References

^ ^a ^b ^c BROMAL – BROMAL HYDRATE, Stillé, A., Maisch, J. M. (1884). The National Dispensatory: Containing the Natural History, Chemistry, Pharmacy, Actions, and Uses of Medicine. Including Those Recognized in the Pharmacopoeias of the United States, Great Britain, and Germany, with Numerous References to the French Codex. H.C. Lea.
^ "Bromal hydrate". pubchem.ncbi.nlm.nih.gov.
^ ^a ^b Bromal Hydrate (page 53), Cerna, D. (1894). Notes on the newer remedies. USA: W.B. Saunders.
^ BENNETT, J. H. (1875). Researches into the Antagonism of Medicines; being the report of the Edinburgh Committee of the British Medical Association ... Reprint from the British Medical Journal. J.&A. Churchill.
^ Bromal Hydrate, E. Steinauer (1871)

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[bromal-1] BROMAL – BROMAL HYDRATE, Stillé, A., Maisch, J. M. (1884). The National Dispensatory: Containing the Natural History, Chemistry, Pharmacy, Actions, and Uses of Medicine. Including Those Recognized in the Pharmacopoeias of the United States, Great Britain, and Germany, with Numerous References to the French Codex. H.C. Lea.

[2] "Bromal hydrate". pubchem.ncbi.nlm.nih.gov.

[cerna-3] Bromal Hydrate (page 53), Cerna, D. (1894). Notes on the newer remedies. USA: W.B. Saunders.

[4] BENNETT, J. H. (1875). Researches into the Antagonism of Medicines; being the report of the Edinburgh Committee of the British Medical Association ... Reprint from the British Medical Journal. J.&A. Churchill.

[5] Bromal Hydrate, E. Steinauer (1871)

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