Bomanin
| Bomanin | |||||||
|---|---|---|---|---|---|---|---|
 The fruit fly, Drosophila melanogaster | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Bom | ||||||
| UniProt | P82706 | ||||||
| |||||||
The Bomanin gene family encodes a group of immune peptides that are essential for Drosophila fruit fly defence against infection by many pathogens.[1][2]
The gene family is named in honour of Hans G. Boman, for his contributions to innate immunity and the discovery of antimicrobial peptides.[1] While Bomanins are essential for survival after infection by many kinds of Gram-positive bacteria and pathogenic fungi, the reason they are key to defence may be because Bomanins promote resilience to pathogen toxins, and not because they directly suppress pathogens.[3] However fly hemolymph (blood) loses its fungicidal activity in the absence of Bomanins, suggesting these peptides are also somehow needed to turn the hemolymph into an antimicrobial environment.[4]
See also
[edit]- Hans G. Boman
- Antimicrobial peptides
- Drosomycin
- Metchnikowin
- Baramicin
- Daisho
- The Toll immunity signalling pathway
References
[edit]- ^ a b Clemmons AW, Lindsay SA, Wasserman SA (April 2015). Silverman N (ed.). "An effector Peptide family required for Drosophila toll-mediated immunity". PLOS Pathogens. 11 (4): e1004876. doi:10.1371/journal.ppat.1004876. PMC 4411088. PMID 25915418.
- ^ Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaitre B (February 2019). "Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach". eLife. 8: e44341. doi:10.7554/eLife.44341. PMC 6398976. PMID 30803481.
- ^ Xu R, Lou Y, Tidu A, Bulet P, Heinekamp T, Martin F, et al. (January 2023). "The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins". EMBO Reports. 24 (1): e56036. doi:10.15252/embr.202256036. PMC 9827548. PMID 36322050.
- ^ Lindsay SA, Lin SJ, Wasserman SA (2018). "Short-Form Bomanins Mediate Humoral Immunity in Drosophila". Journal of Innate Immunity. 10 (4): 306–314. doi:10.1159/000489831. PMC 6158068. PMID 29920489.