Jump to content

Bip internal ribosome entry site (IRES)

From Wikipedia, the free encyclopedia
bip internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Bip
Identifiers
SymbolIRES_Bip
Alt. SymbolsBip_IRES
RfamRF00223
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress.[1]

References

[edit]
  1. ^ Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.
[edit]