Bip internal ribosome entry site (IRES)
Appearance
bip internal ribosome entry site (IRES) | |
---|---|
Identifiers | |
Symbol | IRES_Bip |
Alt. Symbols | Bip_IRES |
Rfam | RF00223 |
Other data | |
RNA type | Cis-reg; IRES |
Domain(s) | Eukaryota |
GO | GO:0043022 |
SO | SO:0000243 |
PDB structures | PDBe |
The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress.[1]
References
[edit]- ^ Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.