Bacillus subtilis type I antitoxin SR6

SR6 is a 100 nucleotide long antisense RNA antitoxin that overlaps 2 toxins: 3' end of yonT and yoyJ at its 5'end. In type I toxin-antitoxin (TA) systems the antitoxin is a small RNA that neutralizes a toxin protein. Several type I TA systems have been described in B. subtilis.^[1] YonT/SR6 system is located on the SPβ prophage of the B. subtilis chromosome and it was shown to be multi-stress responsive. SR6 acts by promoting yonT mRNA degradation. It may regulate the second toxin, yoyJ by a different mechanism.^[2]

Other B. Subtilis type I TA systems

References

^ Durand S, Jahn N, Condon C, Brantl S (December 2012). "Type I toxin-antitoxin systems in Bacillus subtilis". RNA Biology. 9 (12): 1491–1497. doi:10.4161/rna.22358. PMID 23059907.
^ Reif C, Löser C, Brantl S (February 2018). "Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression". Toxins. 10 (2): 74. doi:10.3390/toxins10020074. PMC 5848175. PMID 29414903.

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[1] Durand S, Jahn N, Condon C, Brantl S (December 2012). "Type I toxin-antitoxin systems in Bacillus subtilis". RNA Biology. 9 (12): 1491–1497. doi:10.4161/rna.22358. PMID 23059907.

[2] Reif C, Löser C, Brantl S (February 2018). "Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression". Toxins. 10 (2): 74. doi:10.3390/toxins10020074. PMC 5848175. PMID 29414903.

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