BMX (gene)

BMX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKX, 2YS2, 3SXR, 3SXS
Identifiers
Aliases	BMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase
External IDs	OMIM: 300101; MGI: 1101778; HomoloGene: 20411; GeneCards: BMX; OMA:BMX - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	15,556,529 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	163,041,189 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; right auricle; ; bone marrow; ; cardiac muscle tissue of right atrium; ; testicle; ; right coronary artery; ; subcutaneous adipose tissue; ; right lung; ; Achilles tendon; ; urethra;
	Top expressed in
	granulocyte; ; atrioventricular valve; ; atrium; ; lumbar spinal ganglion; ; tunica media of zone of aorta; ; zygote; ; tibiofemoral joint; ; endocardial cushion; ; right lung lobe; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; signal transducer activity; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding; non-membrane spanning protein tyrosine kinase activity;
Cellular component	cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; ruffle membrane; nucleoplasm; plasma membrane;
Biological process	intracellular signal transduction; phosphorylation; NK T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; cell adhesion; regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; mesoderm development; innate immune response; signal transduction; apoptotic process; phosphatidylinositol biosynthetic process; adaptive immune response; B cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	660
	12169
	ENSG00000102010
	ENSMUSG00000031377
	P51813
	P97504
	NM_001721; NM_203281; NM_001320866
	NM_009759
	NP_001307795; NP_001712; NP_975010
	NP_033889
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.^[5]^[6]

Function

Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.^[6]

Interactions

BMX has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (December 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene. 9 (12): 3683–8. PMID 7970727.
^ ^a ^b "Entrez Gene: BMX BMX non-receptor tyrosine kinase".
^ Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (August 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
^ Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (May 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870. S2CID 23449101.
^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (December 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
^ Yang J, Kim O, Wu J, Qiu Y (August 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.

Robinson D, He F, Pretlow T, Kung HJ (1996). "A tyrosine kinase profile of prostate carcinoma". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 5958–62. Bibcode:1996PNAS...93.5958R. doi:10.1073/pnas.93.12.5958. PMC 39170. PMID 8650201.
Kaukonen J, Lahtinen I, Laine S, et al. (1996). "BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias". Br. J. Haematol. 94 (3): 455–60. doi:10.1111/j.1365-2141.1996.tb00091.x. PMID 8790141. S2CID 22054727.
Ekman N, Lymboussaki A, Västrik I, et al. (1997). "Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries". Circulation. 96 (6): 1729–32. doi:10.1161/01.cir.96.6.1729. PMID 9323053.
Saharinen P, Ekman N, Sarvas K, et al. (1997). "The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta". Blood. 90 (11): 4341–53. doi:10.1182/blood.V90.11.4341. PMID 9373245.
Qiu Y, Robinson D, Pretlow TG, Kung HJ (1998). "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3644–9. Bibcode:1998PNAS...95.3644Q. doi:10.1073/pnas.95.7.3644. PMC 19889. PMID 9520419.
Várnai P, Rother KI, Balla T (1999). "Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells". J. Biol. Chem. 274 (16): 10983–9. doi:10.1074/jbc.274.16.10983. PMID 10196179.
Tsai YT, Su YH, Fang SS, et al. (2000). "Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation". Mol. Cell. Biol. 20 (6): 2043–54. doi:10.1128/MCB.20.6.2043-2054.2000. PMC 110821. PMID 10688651.
Ekman N, Arighi E, Rajantie I, et al. (2000). "The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner". Oncogene. 19 (36): 4151–8. doi:10.1038/sj.onc.1203763. PMID 10962576.
Jui HY, Tseng RJ, Wen X, et al. (2001). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.
Wu YM, Huang CL, Kung HJ, Huang CY (2001). "Proteolytic activation of ETK/Bmx tyrosine kinase by caspases". J. Biol. Chem. 276 (21): 17672–8. doi:10.1074/jbc.M010964200. PMID 11278797.
Chen R, Kim O, Li M, et al. (2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870. S2CID 23449101.
Bagheri-Yarmand R, Mandal M, Taludker AH, et al. (2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.
Vargas L, Nore BF, Berglof A, et al. (2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. 277 (11): 9351–7. doi:10.1074/jbc.M108537200. PMID 11751885.
Yang J, Kim O, Wu J, Qiu Y (2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.
Pan S, An P, Zhang R, et al. (2002). "Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis". Mol. Cell. Biol. 22 (21): 7512–23. doi:10.1128/MCB.22.21.7512-7523.2002. PMC 135657. PMID 12370298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nore BF, Mattsson PT, Antonsson P, et al. (2003). "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases". Biochim. Biophys. Acta. 1645 (2): 123–32. doi:10.1016/S1570-9639(02)00524-1. PMID 12573241.
Zhang R, Xu Y, Ekman N, et al. (2004). "Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway". J. Biol. Chem. 278 (51): 51267–76. doi:10.1074/jbc.M310678200. PMID 14532277.
Chen KY, Huang LM, Kung HJ, et al. (2004). "The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells". Oncogene. 23 (10): 1854–62. doi:10.1038/sj.onc.1207308. PMID 14676838.

External links

Human BMX genome location and BMX gene details page in the UCSC Genome Browser.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102010 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7970727-5] Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CI, Larsson C, Alitalo K (December 1994). "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene. 9 (12): 3683–8. PMID 7970727.

[entrez-6] "Entrez Gene: BMX BMX non-receptor tyrosine kinase".

[pmid11382770-7] Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, Kumar R (August 2001). "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. doi:10.1074/jbc.M103129200. PMID 11382770.

[pmid11331870-8] Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y (May 2001). "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. doi:10.1038/35074500. PMID 11331870. S2CID 23449101.

[pmid11013262-9] Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY, Kung HJ, Ann DK, Shih HM (December 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262.

[pmid11877430-10] Yang J, Kim O, Wu J, Qiu Y (August 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi:10.1074/jbc.M111933200. PMID 11877430.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

Interactions

References

Further reading

External links