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Protein-coding gene in the species Homo sapiens
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene .[ 5]
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene . It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[ 6]
Clinical significance [ edit ] BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer 's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[ 7]
BAG1 has been shown to interact with:
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