Augurin

ECRG4
Identifiers
Aliases	ECRG4, chromosome 2 open reading frame 40, C2orf40, UNQ761/PRO1508, ECRG4 augurin precursor
External IDs	OMIM: 611752; MGI: 1926146; HomoloGene: 11505; GeneCards: ECRG4; OMA:ECRG4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	106,078,155 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,781,738 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; bronchial epithelial cell; ; synovial membrane; ; cartilage tissue; ; right coronary artery; ; tibia; ; synovial joint; ; trachea; ; left coronary artery; ; spinal ganglia;
	Top expressed in
	Epithelium of choroid plexus; ; adrenal gland; ; calvaria; ; vestibular sensory epithelium; ; epithelium of lens; ; intercostal muscle; ; tibiofemoral joint; ; ankle; ; condyle; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity;
Cellular component	extracellular region; transport vesicle; cytoplasmic vesicle; extracellular space; dense core granule; cytoplasm; apical plasma membrane; plasma membrane; membrane;
Biological process	cellular senescence; G1 to G0 transition; anaphase-promoting complex-dependent catabolic process; neuropeptide signaling pathway; central nervous system development; negative regulation of cell population proliferation; response to wounding; vasopressin secretion; positive regulation of corticotropin secretion; positive regulation of corticotropin-releasing hormone secretion; positive regulation of corticosterone secretion; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	84417
	78896
	ENSG00000119147
	ENSMUSG00000026051
	Q9H1Z8
	Q99LS0
	NM_032411
	NM_024283
	NP_115787; NP_115787
	NP_077245
	Wikidata
View/Edit Human	View/Edit Mouse

Augurin is a protein that in humans is encoded by the C2orf40 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119147 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026051 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chromosome 2 open reading frame 40". Retrieved 2018-09-05.

Yue CM, Deng DJ, Bi MX, Guo LP, Lu SH (June 2003). "Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma". World J. Gastroenterol. 9 (6): 1174–8. doi:10.3748/wjg.v9.i6.1174. PMC 4611778. PMID 12800218.
Mori Y, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Kurehara H, Mori R, Tomoda K, Ogawa R, Katada T, Harata K, Fujii Y (October 2007). "Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma". Oncol. Rep. 18 (4): 981–5. PMID 17786363.
Li LW, Yu XY, Yang Y, Zhang CP, Guo LP, Lu SH (October 2009). "Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo". Int. J. Cancer. 125 (7): 1505–13. doi:10.1002/ijc.24513. PMID 19521989. S2CID 12122816.
Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, Kuhnen C, Martin D, Müller O, Sievers S (December 2009). "ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma". BMC Cancer. 9: 447. doi:10.1186/1471-2407-9-447. PMC 2804712. PMID 20017917.
Li W, Liu X, Zhang B, Qi D, Zhang L, Jin Y, Yang H (July 2010). "Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion". J. Exp. Clin. Cancer Res. 29 (1): 89. doi:10.1186/1756-9966-29-89. PMC 2913949. PMID 20598162.
Li LW, Li YY, Li XY, Zhang CP, Zhou Y, Lu SH (February 2011). "A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma". BMC Cancer. 11: 52. doi:10.1186/1471-2407-11-52. PMC 3039630. PMID 21288367.
Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A (2011). "Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury". PLOS ONE. 6 (9): e24609. Bibcode:2011PLoSO...624609P. doi:10.1371/journal.pone.0024609. PMC 3173480. PMID 21935431.
Sabatier R, Finetti P, Adelaide J, Guille A, Borg JP, Chaffanet M, Lane L, Birnbaum D, Bertucci F (2011). "Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer". PLOS ONE. 6 (11): e27656. Bibcode:2011PLoSO...627656S. doi:10.1371/journal.pone.0027656. PMC 3218004. PMID 22110708.
Li LW, Yu XY, Li XY, Guo LP, Zhou Y, Lu SX (August 2011). "[Mechanism of loss of human esophageal cancer-related gene 4 (ECRG4) gene expression in esophageal squamous cell carcinoma cell line EC9706]". Zhonghua Zhong Liu Za Zhi (in Chinese). 33 (8): 570–3. PMID 22325214.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119147 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026051 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Chromosome 2 open reading frame 40". Retrieved 2018-09-05.

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References

Further reading