Arogenate dehydrogenase (NAD(P)+)
Appearance
Arogenate dehydrogenase (NAD(P)+) | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.79 | ||||||||
CAS no. | 64295-75-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, an arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) is an enzyme that catalyzes the chemical reaction
- L-arogenate + NAD(P)+ L-tyrosine + NAD(P)H + CO2
The 3 substrates of this enzyme are L-arogenate, NAD+, and NADP+, whereas its 4 products are L-tyrosine, NADH, NADPH, and CO2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD(P)+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, and pretyrosine dehydrogenase (ambiguous).
References
[edit]- Connelly JA, Conn EE (1986). "Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase". Z. Naturforsch. C. 41 (1–2): 69–78. doi:10.1515/znc-1986-1-212. PMID 2939643.
- Bonner C, Jensen R (1987). "Arogenate dehydrogenase". Metabolism of Aromatic Amino Acids and Amines. Methods in Enzymology. Vol. 142. pp. 488–94. doi:10.1016/S0076-6879(87)42060-0. ISBN 978-0-12-182042-8. PMID 3600376.