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Aphthovirus internal ribosome entry site (IRES)

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Aphthovirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Aptho
Identifiers
SymbolIRES_Aptho
Alt. SymbolsAptho_IRES
RfamRF00210
Other data
RNA typeCis-reg; IRES
Domain(s)Viruses
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

This family represents the internal ribosome entry site (IRES) of the Picornaviruses.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.[2]

References

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  1. ^ Fernández-Miragall O, Martínez-Salas E (November 2003). "Structural organization of a viral IRES depends on the integrity of the GNRA motif" (PDF). RNA. 9 (11): 1333–1344. doi:10.1261/rna.5950603. PMC 1287055. PMID 14561883.
  2. ^ Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.
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