Annexin A3

ANXA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AII, 1AXN
Identifiers
Aliases	ANXA3, ANX3, annexin A3
External IDs	OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.21 Start 78,551,747 bp End 78,610,451 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E3|5 47.29 cM Start 96,941,198 bp End 96,993,825 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung germinal epithelium bone marrow upper lobe of left lung bone marrow cells minor salivary glands left lobe of thyroid gland trabecular bone right lobe of thyroid gland body of stomach Top expressed in right lung lobe mucous cell of stomach pyloric antrum endothelial cell of lymphatic vessel left lung granulocyte left lung lobe decidua epithelium of stomach gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase inhibitor activity calcium ion binding phospholipase A2 inhibitor activity calcium-dependent protein binding calcium-dependent phospholipid binding Cellular component cytoplasm phagocytic vesicle membrane membrane plasma membrane axon soma dendrite specific granule extracellular exosome cytosol Biological process negative regulation of catalytic activity positive regulation of DNA metabolic process neutrophil degranulation positive regulation of DNA-binding transcription factor activity response to glucocorticoid positive regulation of angiogenesis positive regulation of endothelial cell migration defense response to bacterium animal organ regeneration phagocytosis response to growth factor hippocampus development homophilic cell adhesion via plasma membrane adhesion molecules regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 306 11745 Ensembl ENSG00000138772 ENSMUSG00000029484 UniProt P12429 O35639 RefSeq (mRNA) NM_005139 NM_013470 RefSeq (protein) NP_005130 NP_038498 Location (UCSC) Chr 4: 78.55 – 78.61 Mb Chr 5: 96.94 – 96.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.

External links

• Human ANXA3 genome location and ANXA3 gene details page in the UCSC Genome Browser.

Further reading

• Ernst JD, Hoye E, Blackwood RA, Jaye D (1990). "Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules". J. Clin. Invest. 85 (4): 1065–71. doi:10.1172/JCI114537. PMC 296536. PMID 2138632.
• Ross TS, Tait JF, Majerus PW (1990). "Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III". Science. 248 (4955): 605–7. Bibcode:1990Sci...248..605R. doi:10.1126/science.2159184. PMID 2159184.
• Pepinsky RB, Tizard R, Mattaliano RJ, et al. (1988). "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I." J. Biol. Chem. 263 (22): 10799–811. doi:10.1016/S0021-9258(18)38041-4. PMID 2968983.
• Tait JF, Sakata M, McMullen BA, et al. (1989). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry. 27 (17): 6268–76. doi:10.1021/bi00417a011. PMID 2975506.
• Tait JF, Smith C, Xu L, Cookson BT (1994). "Structure and polymorphisms of the human annexin III (ANX3) gene". Genomics. 18 (1): 79–86. doi:10.1006/geno.1993.1428. PMID 8276419.
• Sekar MC, Sambandam V, Grizzle WE, McDonald JM (1996). "Dissociation of cyclic inositol phosphohydrolase activity from annexin III". J. Biol. Chem. 271 (14): 8295–9. doi:10.1074/jbc.271.14.8295. PMID 8626524.
• Favier-Perron B, Lewit-Bentley A, Russo-Marie F (1996). "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.". Biochemistry. 35 (6): 1740–4. doi:10.1021/bi952092o. PMID 8639653.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. S2CID 195213008.
• Bödeker H, Keim V, Fiedler F, et al. (2000). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Mol. Cell Biol. Res. Commun. 2 (3): 150–4. doi:10.1006/mcbr.1999.0166. PMID 10662590.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Park JE, Lee DH, Lee JA, et al. (2005). "Annexin A3 is a potential angiogenic mediator". Biochem. Biophys. Res. Commun. 337 (4): 1283–7. doi:10.1016/j.bbrc.2005.10.004. PMID 16236264.