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Anne-Claude Gingras

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Anne-Claude Gingras
Born
Île d'Orléans, Quebec, Canada
NationalityCanadian
Alma mater
Known forQuantitative proteomics
Scientific career
Institutions

Anne-Claude Gingras FRSC is a senior investigator at Lunenfeld-Tanenbaum Research Institute, and a professor in the department of molecular genetics at the University of Toronto.[1] She is an expert in mass spectrometry based proteomics technology that allows identification and quantification of protein from various biological samples.

Biography

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Gingras was born on Île d'Orléans, Quebec.[2] She earned her undergraduate degree at Université Laval in Quebec.[3] She completed her PhD in biochemistry at McGill University in Montreal,[2] studying how 4E-BP1 regulated translation initiation, under the mentorship of Nahum Sonenberg.[3] After graduating in 2001, she began postdoctoral research in Seattle at the Institute for Systems Biology in the lab of Ruedi Aebersold, where she studied proteomics for three years.[3]

In 2005, Gingras moved to Toronto and joined the Lunenfeld-Tanenbaum Research Institute, and in 2006 began teaching at the University of Toronto in the department of molecular genetics.[2]

Career

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Gingras research focuses on the development of experimental and bioinformatics approaches for functional proteomics, with a focus on protein-protein and proximity interactions. She applies these tools to the study of signaling pathways in health and disease and in mapping the physical organization of the dynamic proteome. Some of her work focuses on the consequence of disease-associated mutations on the interactions established by proteins.[4]

In addition to proteomics, Gingras laboratory has interest in studying human protein phosphatase and their systematic interactions and has now expanded into the field of systems biology.

Achievements and awards

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Gingras has published > 200 articles that have been cited > 35,000 times (Google Scholar; Feb 2020). In 2011, Gingras was named one of Canada's Top 100 Most Powerful Women.[2][5] In 2015, Gingras was elected a fellow of the Royal Society of Canada.[6] Her work on interaction proteomics, was awarded, alongside John Yates, the Discovery Award in Proteomics from the Human Proteome Organization (2019). She also received the Jeanne Manery Fisher Memorial Lecture award at the 2019 meeting of the Canadian Society for Molecular Biosciences.[7]

Selected publications

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  • Gingras, Anne-Claude; Raught, Brian; Sonenberg, Nahum (1999-06-01). "eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation". Annual Review of Biochemistry. 68 (1): 913–963.[8]
  • Sonenberg, Nahum; Lawrence, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Pause, Arnim (1994-10). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–767.[9]
  • Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (2001-04-01). "Regulation of translation initiation by FRAP/mTOR". Genes & Development. 15(7): 807–826.[10]
  • Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude (1999-06-01). "Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism". Genes & Development. 13 (11): 1422–1437.[11]
  • Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Kennedy, Scott G.; Gingras, Anne-Claude (1998-02-15). "4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway". Genes & Development. 12 (4): 502–513.[12]
  • Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (2001-11-01). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1". Genes & Development. 15 (21): 2852–2864.[13]
  • Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (2001-06-19). "The target of rapamycin (TOR) proteins". Proceedings of the National Academy of Sciences. 98 (13): 7037–7044.[14]

References

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  1. ^ Government of Canada, Canadian Institutes of Health Research (15 December 2017). "IG Institute Advisory Board Members – Biographies - CIHR". www.cihr-irsc.gc.ca. Retrieved 6 May 2019.
  2. ^ a b c d "Dr. Anne-Claude Gingras named one of Canada's Top 100 Most Powerful Women | Lunenfeld-Tanenbaum". www.mshri.on.ca. Retrieved 6 May 2019.
  3. ^ a b c "Feature | Meet Anne-Claude Gingras". www.asbmb.org. Retrieved 6 May 2019.
  4. ^ "Venture philanthropy: Medical research meets Dragons' Den". Retrieved 6 May 2019.
  5. ^ "100 most powerful women in Canada | The Star". thestar.com. 6 December 2011. Retrieved 6 May 2019.
  6. ^ "FELLOWS DIRECTORY | The Royal Society of Canada". rsc-src.ca. Retrieved 6 May 2019.
  7. ^ "Canada's unsung female heroes of life sciences : Med e-News". Retrieved 6 May 2019.
  8. ^ Gingras, Anne-Claude; Raught, Brian; Sonenberg, Nahum (1 June 1999). "eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation". Annual Review of Biochemistry. 68 (1): 913–963. doi:10.1146/annurev.biochem.68.1.913. ISSN 0066-4154. PMID 10872469.
  9. ^ Sonenberg, Nahum; Lawrence, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Pause, Arnim (October 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–767. Bibcode:1994Natur.371..762P. doi:10.1038/371762a0. ISSN 1476-4687. PMID 7935836. S2CID 4360955.
  10. ^ Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (1 April 2001). "Regulation of translation initiation by FRAP/mTOR". Genes & Development. 15 (7): 807–826. doi:10.1101/gad.887201. ISSN 0890-9369. PMID 11297505.
  11. ^ Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude (1 June 1999). "Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism". Genes & Development. 13 (11): 1422–1437. doi:10.1101/gad.13.11.1422. ISSN 0890-9369. PMC 316780. PMID 10364159.
  12. ^ Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Kennedy, Scott G.; Gingras, Anne-Claude (15 February 1998). "4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway". Genes & Development. 12 (4): 502–513. doi:10.1101/gad.12.4.502. ISSN 0890-9369. PMC 316523. PMID 9472019.
  13. ^ Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (1 November 2001). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1". Genes & Development. 15 (21): 2852–2864. doi:10.1101/gad.912401. ISSN 0890-9369. PMC 312813. PMID 11691836.
  14. ^ Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (19 June 2001). "The target of rapamycin (TOR) proteins". Proceedings of the National Academy of Sciences. 98 (13): 7037–7044. Bibcode:2001PNAS...98.7037R. doi:10.1073/pnas.121145898. ISSN 0027-8424. PMC 34619. PMID 11416184.
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