Aldehyde dehydrogenase 9 family, member A1

ALDH9A1
Identifiers
Aliases	ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH
External IDs	OMIM: 602733; MGI: 1861622; HomoloGene: 55483; GeneCards: ALDH9A1; OMA:ALDH9A1 - orthologs
EC number	1.2.1.3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,698,562 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,196,101 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; salivary gland; ; minor salivary glands; ; mucosa of esophagus; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; liver; ; corpus callosum;
	Top expressed in
	left lobe of liver; ; retinal pigment epithelium; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; human kidney; ; migratory enteric neural crest cell; ; ciliary body; ; jejunum; ; ileum; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aldehyde dehydrogenase (NAD+) activity; oxidoreductase activity; aminobutyraldehyde dehydrogenase activity; 1-pyrroline dehydrogenase activity; 4-trimethylammoniobutyraldehyde dehydrogenase activity; 3-chloroallyl aldehyde dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;
Cellular component	cytoplasm; extracellular exosome; cytosol;
Biological process	cellular aldehyde metabolic process; hormone metabolic process; metabolism; neurotransmitter biosynthetic process; carnitine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	223
	56752
	ENSG00000143149
	ENSMUSG00000026687
	P49189
	Q9JLJ2
	NM_000696; NM_001365774
	NM_019993
	NP_000687; NP_001352703
NP_064377; NP_001389759; NP_001389768; NP_001389769; NP_001389773;
	NP_001389774; NP_001389775; NP_001392024
	Wikidata
View/Edit Human	View/Edit Mouse

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.^[5]^[6]^[7]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde (GABAL) and other amino aldehydes. The enzyme catalyzes the dehydrogenation of GABAL to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143149 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026687 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751. S2CID 26773065.
^ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
^ ^a ^b "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

Human ALDH9A1 genome location and ALDH9A1 gene details page in the UCSC Genome Browser.

Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. doi:10.1016/S0021-9258(18)83802-9. PMID 2925663.
Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. doi:10.1042/bj3160317. PMC 1217341. PMID 8645224.
Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142. S2CID 35621262.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143149 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026687 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8112751-5] McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751. S2CID 26773065.

[pmid8786138-6] Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.

[entrez-7] "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

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v t e Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2 (mitochondrial)	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

Function

References

External links

Further reading