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Akihiro Kusumi

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Akihiro Kusumi
楠見 明弘
BornOctober 1952 (1952-10) (age 72)
NationalityJapanese
Alma materKyoto University
Known forProposing the membrane-skeleton fence model to explain hop diffusion
Scientific career
FieldsBiophysics, Molecular biology
InstitutionsOkinawa Institute of Science and Technology (from 2021)

Akihiro Kusumi (楠見 明弘, Kusumi Akihiro, born October 1952[1]) is a Japanese biologist who proposed an explanation for reduced diffusion speed of lipid and protein molecules in the cell membrane, based on a model of hop diffusion in which lipids are confined to a reduced space, created by membrane-skeleton-induced compartments. These compartments allow the lipids or proteins to diffuse freely in a limited region and also limit the diffusion to neighboring compartments on the membrane. Getting to a new compartment is called "hop diffusion" while diffusion in the compartment is allowed by Brownian movement, the compartments of the cell are responsible of the reduced diffusion speed of the lipid or proteins when compared to artificial vesicles.[2]

Citations

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  • JCB article on "hop diffusion"
  • Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. struct. 2005. 34:351-78. doi: 10.1146/annurev.biophys.34.040204.144637. [1]

References

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  1. ^ a b "平成10年度発足4プロジェクト決定". JSTニュース (in Japanese). 24: 2–5. 1998.
  2. ^ Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. struct. 2005. 34:351-78. doi: 10.1146/annurev.biophys.34.040204.144637
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