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Ahna Skop

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Ahna Skop
Born1972[1]
New Haven, Connecticut
OccupationProfessor of Genetics
Academic background
EducationSyracuse University: B.S. Biology (1994)

University of Wisconsin-Madison: Ph.D. Cellular and Molecular Biology (2000)

UC Berkeley: Post Doctorate Work
Alma materUniversity of Wisconsin Madison
ThesisStudies on cleavage plane orientation and daughter cell separation in Caenorhabditis elegans (2000)
Doctoral advisorJohn G. White
Other advisorsBarbara Meyer, Rebecca Heald
Academic work
DisciplineCell Biologist
Sub-disciplineArtist
InstitutionsUniversity of Wisconsin-Madison

Ahna Renee Skop is an American geneticist, artist, and a professor at the University of Wisconsin–Madison. She is known for her research on the mechanisms underlying asymmetric cell division, particularly the importance of the midbody in this process.

Education

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Skop grew up in New Haven, Connecticut and Fort Thomas, Kentucky.[2] She earned a Bachelor of Science in biology and a minor in Ceramics from Syracuse University and before completing her Ph.D. in cellular and molecular biology at the University of Wisconsin-Madison. She did postdoctoral work at the University of California, Berkeley in the laboratories of Rebecca Heald, Barbara Meyer and John Yates (Scripps),[3] after which she returned to the University of Wisconsin–Madison where, as of 2018, she is a full professor of genetics.[2]

Career

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Skop is known for her work on Caenorhabditis elegans, a free-living worm, and mammalian tissue culture cells where she has studied the mechanisms that control cell division. Her early work was on the final stages of cell division in C. elegans,[4][5] and she identified the proteins in the midbody that are involved in cell division.[6] Her more recent work examines defects that could be caused by problems in the mammalian midbody, where she has shown that midbody is an organelle that harbors translationally active RNA.[7]

As a faculty member, Skop guided the creation of a diversity committee within the genetics department in the College of Agriculture and Life Sciences at the University of Madison-Wisconsin and led the creation of their STEM Diversity Network.[8]

Skop collaborated with undergraduate students Elif Kurt and Caitlin Marks to release Genetics Reflections: A coloring book in 2020.[9]

Artistic career

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Skop has curated a scientific art show at the International C. elegans meeting, the "Worm Art Show",[10] and she worked with a Madison, Wisconsin artist, Angela Johnson to create an art installation called "Genetic Reflections".[11]

Select publications

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  • Jung GI, Londoño-Vásquez D, Park S, Skop AR, Balboula AZ, Schindler K. An oocyte meiotic midbody cap is required for developmental competence in mice. Nat Commun. 2023 Nov 16;14(1):7419. doi: 10.1038/s41467-023-43288-x. PMID: 37973997; PMCID: PMC10654508.
  • Park S, Patel SA, Torr EE, Dureke AN, McIntyre AM, Skop AR. A protocol for isolating and imaging large extracellular vesicles or midbody remnants from mammalian cell culture. STAR Protoc. 2023 Dec 15;4(4):102562. doi: 10.1016/j.xpro.2023.102562. Epub 2023 Sep 9. PMID: 37690025; PMCID: PMC10500451.
  • Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, Blower M, Skop AR. The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation. Dev Cell. 2023 Oct 9;58(19):1917-1932.e6. doi: 10.1016/j.devcel.2023.07.009. Epub 2023 Aug 7. PMID: 37552987; PMCID: PMC10592306.
  • Skop, Ahna R.; Bergmann, Dominique; Mohler, William A.; White, John G. (2001-05-15). "Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex". Current Biology. 11 (10): 735–746. Bibcode:2001CBio...11..735S. doi:10.1016/S0960-9822(01)00231-7. ISSN 0960-9822. PMC 3733387. PMID 11378383.
  • Skop, Ahna R.; Liu, Hongbin; Yates, John; Meyer, Barbara J.; Heald, Rebecca (2004-07-02). "Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms". Science. 305 (5680): 61–66. Bibcode:2004Sci...305...61S. doi:10.1126/science.1097931. ISSN 0036-8075. PMC 3679889. PMID 15166316.
  • Skop, Ahna R.; White, John G. (1998-10-08). "The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos". Current Biology. 8 (20): 1110–1117. Bibcode:1998CBio....8.1110S. doi:10.1016/S0960-9822(98)70465-8. ISSN 0960-9822. PMC 3690630. PMID 9778526.
  • Thompson, Heather M.; Skop, Ahna R.; Euteneuer, Ursula; Meyer, Barbara J.; McNiven, Mark A. (2002-12-23). "The Large GTPase Dynamin Associates with the Spindle Midzone and Is Required for Cytokinesis". Current Biology. 12 (24): 2111–2117. Bibcode:2002CBio...12.2111T. doi:10.1016/S0960-9822(02)01390-8. ISSN 0960-9822. PMC 3690653. PMID 12498685.
  • Otegui, Marisa S.; Verbrugghe, Koen J.; Skop, Ahna R. (2005-08-01). "Midbodies and phragmoplasts: analogous structures involved in cytokinesis". Trends in Cell Biology. 15 (8): 404–413. doi:10.1016/j.tcb.2005.06.003. ISSN 0962-8924. PMC 3677513. PMID 16009554.
President Bush with the Skop and other recipients of the 2006 Presidential Early Career Awards for Scientists and Engineers

Honors and awards

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References

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  1. ^ a b Skop, Ahna R. (2018-11-01). "The entrance: how life experience shaped my passion for diversity and inclusion". Molecular Biology of the Cell. 29 (22): 2608–2610. doi:10.1091/mbc.E18-07-0431. ISSN 1059-1524. PMC 6249843. PMID 30376436.
  2. ^ a b c "Meet Ahna Skop". www.asbmb.org. Retrieved 2022-05-24.
  3. ^ "Ahna Skop". Wisconsin Institute for Discovery. 2018-04-04. Retrieved 2022-12-17.
  4. ^ Skop, Ahna R.; Bergmann, Dominique; Mohler, William A.; White, John G. (2001-05-15). "Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex". Current Biology. 11 (10): 735–746. Bibcode:2001CBio...11..735S. doi:10.1016/S0960-9822(01)00231-7. ISSN 0960-9822. PMC 3733387. PMID 11378383.
  5. ^ Skop, Ahna R.; White, John G. (1998-10-08). "The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos". Current Biology. 8 (20): 1110–1117. Bibcode:1998CBio....8.1110S. doi:10.1016/S0960-9822(98)70465-8. ISSN 0960-9822. PMC 3690630. PMID 9778526.
  6. ^ Skop, Ahna R.; Liu, Hongbin; Yates, John; Meyer, Barbara J.; Heald, Rebecca (2004-07-02). "Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms". Science. 305 (5680): 61–66. Bibcode:2004Sci...305...61S. doi:10.1126/science.1097931. ISSN 0036-8075. PMC 3679889. PMID 15166316.
  7. ^ Gnazzo, Megan M.; Uhlemann, Eva-Maria E.; Villarreal, Alex R.; Shirayama, Masaki; Dominguez, Eddie G.; Skop, Ahna R. (2016-10-15). "The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4". Molecular Biology of the Cell. 27 (20): 3052–3064. doi:10.1091/mbc.e16-04-0219. ISSN 1059-1524. PMC 5063614. PMID 27559134.
  8. ^ a b Lotlikar, Sarina (2020-01-31). "UW–Madison to Hold 12th Annual Reception Honoring Outstanding Women of Color". Diversity, Equity & Inclusion. Retrieved 2024-08-17.
  9. ^ "Science coloring book brings excitement and community to kids and adults alike". University of Wisconsin-Madison. 2021-02-24. Retrieved 2024-08-17.
  10. ^ Hopkin, Karen (April 2012). "Truth and Beauty". The Scientist; Midland. 26 (4): 56–58 – via ProQuest.
  11. ^ "'Genetic Reflections' exhibit at LU inspires related art and science events". The Post - Crescent; Appleton, Wis. [Appleton, Wis]. 10 November 2019. pp. C.1 – via ProQuest.
  12. ^ "The Presidential Early Career Award for Scientists and Engineers: Recipient Details | NSF - National Science Foundation". www.nsf.gov. Retrieved 2022-05-24.
  13. ^ "Awards - CSB & Joint". College of Saint Benedict & Saint John's University. Retrieved 2022-12-14.
  14. ^ "Ahna Skop". Interalia Magazine. 2017-07-03. Retrieved 2024-08-17.
  15. ^ "Ahna Skop honored with UW Distinguished Teaching Award – CALS News". CALS News – College of Agricultural & Life Sciences. 2016-03-05. Retrieved 2024-08-17.
  16. ^ "If/THEN® Ambassadors Reach Millions of Girls, Sharing Scientists' Human Side and the Wonders of Science". American Association for the Advancement of Science (AAAS). 2021-12-15. Retrieved 2024-08-17.
  17. ^ "Professor Ahna Skop awarded Vilas Faculty Mid-Career Investigator Award". Genetics. 2022-12-07. Retrieved 2024-08-17.
  18. ^ "Genetics professor Ahna Skop elected into the Wisconsin Academy class of 2024". Genetics. 2024-03-15. Retrieved 2024-08-17.
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