Afabicin
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Other names | AFN-1720; Debio1450 |
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Formula | C23H24N3O7P |
Molar mass | 485.433 g·mol−1 |
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Afabicin (Debio 1450) is an experimental antibiotic developed by Debiopharm for the treatment of Staphylococcus aureus infections. It is a prodrug which is converted in vivo into the active form afabicin desphosphono (Debio 1452) which acts as an inhibitor of the staphylococcal enoyl-acyl carrier protein reductase (FabI) enzyme. It has shown similar efficacy in clinical trials to established drugs such as vancomycin, but has not yet been approved for clinical use.[1][2][3][4][5][6]
See also
[edit]References
[edit]- ^ Menetrey A, Janin A, Pullman J, Overcash JS, Haouala A, Leylavergne F, et al. (March 2019). "Bone and Joint Tissue Penetration of the Staphylococcus-Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery". Antimicrobial Agents and Chemotherapy. 63 (3). doi:10.1128/AAC.01669-18. PMC 6395911. PMID 30559136.
- ^ Bassetti M, Del Puente F, Magnasco L, Giacobbe DR (May 2020). "Innovative therapies for acute bacterial skin and skin-structure infections (ABSSSI) caused by methicillin-resistant Staphylococcus aureus: advances in phase I and II trials". Expert Opinion on Investigational Drugs. 29 (5): 495–506. doi:10.1080/13543784.2020.1750595. PMID 32242469.
- ^ Wittke F, Vincent C, Chen J, Heller B, Kabler H, Overcash JS, et al. (September 2020). "Afabicin, a First-in-Class Antistaphylococcal Antibiotic, in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Clinical Noninferiority to Vancomycin/Linezolid". Antimicrobial Agents and Chemotherapy. 64 (10). doi:10.1128/AAC.00250-20. PMC 7508579. PMID 32747361.
- ^ Ruggieri F, Compagne N, Antraygues K, Eveque M, Flipo M, Willand N (August 2023). "Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance". European Journal of Medicinal Chemistry. 256: 115413. doi:10.1016/j.ejmech.2023.115413. PMID 37150058.
- ^ Bibens L, Becker JP, Dassonville-Klimpt A, Sonnet P (March 2023). "A Review of Fatty Acid Biosynthesis Enzyme Inhibitors as Promising Antimicrobial Drugs". Pharmaceuticals. 16 (3): 425. doi:10.3390/ph16030425. PMC 10054515. PMID 36986522.
- ^ Nowakowska J, Cameron DR, De Martino A, Kühn J, Le Fresne-Languille S, Leuillet S, et al. (August 2023). "Evaluation of the microbiota-sparing properties of the anti-staphylococcal antibiotic afabicin". The Journal of Antimicrobial Chemotherapy. 78 (8): 1900–1908. doi:10.1093/jac/dkad181. PMC 10393889. PMID 37294305.