Jump to content

APEH (gene)

From Wikipedia, the free encyclopedia
APEH
Identifiers
AliasesAPEH, AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH, acylaminoacyl-peptide hydrolase
External IDsOMIM: 102645; MGI: 88041; HomoloGene: 1240; GeneCards: APEH; OMA:APEH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001640

NM_146226

RefSeq (protein)

NP_001631

NP_666338

Location (UCSC)Chr 3: 49.67 – 49.68 MbChr 9: 107.96 – 107.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acylamino-acid-releasing enzyme is an enzyme that in humans is encoded by the APEH gene.[5][6]

This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively-damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small-cell lung carcinoma and renal cell carcinoma.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164062Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032590Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Erlandsson R; Bergerheim US; Boldog F; Marcsek Z; Kunimi K; Lin BY; Ingvarsson S; Castresana JS; Lee WH (Oct 1990). "A gene near the D3F15S2 site on 3p is expressed in normal human kidney but not or only at a severely reduced level in 11 of 15 primary renal cell carcinomas (RCC)". Oncogene. 5 (8): 1207–11. PMID 2392324.
  6. ^ a b "Entrez Gene: APEH N-acylaminoacyl-peptide hydrolase".
[edit]

Further reading

[edit]